BBa_J36835
1
BBa_J36835
Lipoprotein signal peptide
2006-10-28T11:00:00Z
2015-08-31T04:08:47Z
E. coli K12 genome
This codes for the 20-amino-acid signal peptide and the 1st nine amino acids of lipoprotein. When fused with another protein downstream, the signal peptide should target the protein to the outer membrane of E. coli, facing the periplasm.
This part was fused with OmpA(aa46-66) and OmpA(aa46-159) in trying to express streptavidin protein on the outer surface of E. coli.
false
false
_65_
0
1229
65
Not in stock
true
There is no spacer nucleotide between the part and the SpeI restriction site, so that after BioBricks assembly, the mixed site is 6 base pairs, and the reading frame is maintained between protein domains.
false
Perry Tsai
BBa_J36836
1
BBa_J36836
Outer membrane protein A, aa 46-66
2006-10-28T11:00:00Z
2015-08-31T04:08:47Z
E. coli K12
This part codes for amino acids #46-66 of outer membrane protein A (OmpA). It corresponds to a single transmembrane domain of OmpA, crossing the outer membrane of E. coli.
This was fused with the lipoprotein signal peptide upstream and streptavidin downstream in the project to express streptavidin on the outer surface of E. coli.
false
false
_65_
0
1229
65
Not in stock
false
There are no spacer nucleotides between the part and the XbaI restriction site, or between the part and the SpeI restriction site, so that the mixed site would be 6bp long, and reading frame would be maintained between protein domains.
false
Perry Tsai
BBa_J36844
1
BBa_J36844
Lpp-OmpA(46-66)-Streptavidin wild-type + His6
2006-10-30T12:00:00Z
2015-08-31T04:08:47Z
Assembly of J36835, J36836, and J36841
Assembled construct of signal peptide of lipoprotein, one transmembrane domain of outer membrane protein A, and streptavidin, wild-type with His6 tag at the end.
This construct codes for a protein which displays streptavidin on the cell surface.
false
false
_65_
0
1229
65
It's complicated
false
There are no spacer nucleotides between the part and the XbaI restriction site, or between the part and the SpeI restriction site, so that the mixed site would be 6bp long, and reading frame would be maintained between protein domains.
Also, the mixed site in between the parts is only six base pairs long, ACTAGA, without the spacer T or G in between parts.
false
Perry Tsai
component1909016
1
BBa_J36841
component1909014
1
BBa_J36835
component1909015
1
BBa_J36836
annotation1909015
1
BBa_J36836
range1909015
1
96
158
annotation1909014
1
BBa_J36835
range1909014
1
1
87
annotation1909016
1
BBa_J36841
range1909016
1
167
571
BBa_J36841
1
BBa_J36841
Streptavidin, wild-type core + His6 tag (no start codon)
2006-10-28T11:00:00Z
2015-08-31T04:08:47Z
PCR off a plasmid obtained from Alice Ting's lab at MIT.
This part codes for the core part of wild-type streptavidin protein, without the start codon. Streptavidin protein binds strongly to the biotin molecule, and can be used to bind biotinylated nucleic acids or peptides.
There is a histidine tag added at the end of the coding sequence right before the stop codons. You can probe for this protein with an anti-his(C-term) antibody.
It was used as part of a fusion protein with lipoprotein signal peptide and outer membrane protein A transmembrane domains, to express streptavidin on the outer surface of E. coli.
false
false
_65_
0
1229
65
Not in stock
true
There was originally a XbaI site TCTAGA at nucleotides 118-123 of the part, which was mutated to AGCCGC. It is missing its start codon at the beginning, as the intention was to fuse this with surface display domains upstream.
There are no spacer nucleotides between the part and the XbaI restriction site, or between the part and the SpeI restriction site, so that the mixed site would be 6bp long, and reading frame would be maintained between protein domains.
false
Perry Tsai
BBa_J36841_sequence
1
gctgaagctggtatcaccggcacctggtacaaccagctgggatccaccttcatcgttaccgctggtgctgacggtgctctgaccggtacctacgaatccgctgttggtaacgctgaaagccgctacgttctgaccggtcgttacgactccgctccggctaccgacggttccggaaccgctctgggttggaccgttgcttggaaaaacaactaccgtaacgctcactccgctaccacctggtctggccagtacgttggtggtgctgaagctcgtatcaacacccagtggttgttgacctccggcaccaccgaagccaacgcgtggaaatccaccctggttggtcacgacaccttcaccaaagttaaaccgtccgctgcttcccatcaccatcaccaccattaataa
BBa_J36835_sequence
1
atgaaagctactaaactggtactgggcgcggtaatcctgggttctactctgctggcaggttgctccagcaacgctaaaatcgatcag
BBa_J36844_sequence
1
atgaaagctactaaactggtactgggcgcggtaatcctgggttctactctgctggcaggttgctccagcaacgctaaaatcgatcagtactagagaacccgtatgttggctttgaaatgggttacgactggttaggtcgtatgccgtacaaaggcagctactagaggctgaagctggtatcaccggcacctggtacaaccagctgggatccaccttcatcgttaccgctggtgctgacggtgctctgaccggtacctacgaatccgctgttggtaacgctgaaagccgctacgttctgaccggtcgttacgactccgctccggctaccgacggttccggaaccgctctgggttggaccgttgcttggaaaaacaactaccgtaacgctcactccgctaccacctggtctggccagtacgttggtggtgctgaagctcgtatcaacacccagtggttgttgacctccggcaccaccgaagccaacgcgtggaaatccaccctggttggtcacgacaccttcaccaaagttaaaccgtccgctgcttcccatcaccatcaccaccattaataa
BBa_J36836_sequence
1
aacccgtatgttggctttgaaatgggttacgactggttaggtcgtatgccgtacaaaggcagc
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z