BBa_K1026009
1
BBa_K1026009
A rationally designed promoter negative regulated by CcaR
2013-09-26T11:00:00Z
2015-05-08T01:08:46Z
Synechocystissp. PCC 6803
By fusing G-box, a region that CcaR binds, with the constitutive promoter, BBa_J23107, we devised a promoter that is constitutive without active CcaR (the transcription factor in green light sensor system, CcaS-CcaR-PcpcG2), but be inhibited when CcaR is activated by green light.
false
false
_1333_
0
12098
9
Not in stock
true
We discovered a segment around the -35 region of BBa_J23107 that is almost identical to G-box, the binding region of CcaR on PcpcG2.
So we put the G-box onto this exact region, between -35 region and -10 region of the original promoter.
Therefore, we expect that activated CcaR will bind and hinder RNA polymerase binding, and thus prevents transcription initialization.
false
Hongyi WU
BBa_K1026009_sequence
1
ctttccgatttctttacgattttctccgccctaggtattatgctagc
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z