BBa_K1315000 1 BBa_K1315000 pqsR 2014-09-19T11:00:00Z 2015-05-08T01:09:48Z The source of this part is the genome of Pseudomonas aeruginosa PAO1 provided by the Robert Ryan lab in the Molecular Microbiology department of the University of Dundee, UK. The Pseydomonas quinolone signal (PQS) as well as its precursor 2-heptyl-4-quinolone (HHQ)are very important in mechanisms controlling virulence in Pseudomonas aeruginosa. P. aeruginosa has a key role in Cystic Fibrosis (CF). PQS can initiate signalling for various processes like virulence, motility, and biofilm formation. A good number of these processes are facilitated by PqsR, which is a transcriptional factor. An activated PqsR will go to the nucleus of the cells and activate the respective genes. http://www.ncbi.nlm.nih.gov/pubmed/21539583 http://www.ncbi.nlm.nih.gov/pubmed/?term=pqsr-dependent+and+pqsr-independent+regulation+of+motility+and+biofilm+formation+by+pqs http://www.ncbi.nlm.nih.gov/pubmed/12393198 true false _1690_ 0 21812 9 Discontinued false The sequence did not have any restriction sites to remove so it was immediately PCRed out of the genome and had the registry prefix and suffix added to it. It was then ligated into the pSB1C3 vector. false Dimitrios Michailidis annotation2384759 1 PqsR range2384759 1 1 999 BBa_K1315000_sequence 1 atgcctattcataacctgaatcacgtgaacatgttcctccaggtcatcgcctccggttcgatttcctccgctgcgcggatcctgcgcaagtcgcacaccgcggtcagctcggcggtcagcaacctggaaatcgacctgtgcgtggagctggtccgtcgggacggctacaaggtcgaacccaccgagcaggcgcttcgcctgatcccttacatgcgcagcctgctgaactaccagcagctgatcggcgacatcgccttcaatctcaacaagggtccgcgcaatctccgggtgctgctggacaccgccatcccgccgtcgttctgcgatacggtgagcagcgtactgctcgacgatttcaacatggtcagcctgatacgcacctcgcccgccgatagcctggcgacgatcaagcaggacaacgcggaaatcgatatcgccatcaccatcgacgaggaactgaagatctcccgcttcaaccagtgcgtgctcggctacaccaaggcgttcgtcgtcgcccatccgcagcacccgttgtgcaatgcctccctgcacagcatcgcgagcctggccaattaccggcagatcagcctcggcagccgctccgggcagcattcgaacctgctgcggccggtcagcgacaaggtgctcttcgtggaaaacttcgacgacatgctgcgtctggtggaagccggcgtcggatggggcatcgcgccgcattatttcgtcgaggaacgcctgcgcaacggtaccctggcagtcctcagcgaactctacgaaccgggcggcatcgacaccaaggtgtattgctactacaacaccgcgctggaatccgagcgcagcttcctgcgctttctcgaaagcgcccgccagcgcctgcgcgaactcggccgccagcgtttcgacgatgcgccggcctggcaaccgagcatcgtcgaaacggcgcagcgccgctcaggcccgaaggcgctcgcgtaccgccagcgcgccgcaccagagtag igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z