BBa_K1458002 1 BBa_K1458002 ucp1 (Uncoupling protein 1) 2014-10-04T11:00:00Z 2015-05-08T01:10:32Z http://www.ncbi.nlm.nih.gov/gene/7350#genomic-regions-transcripts-products ucp1 is the gene encoding UCP1 protein. it is a Transmembrane protein naturally present in mitochondrias of brown adipose tissue. the gene itself is not encoded though in the mitochondrial genome but in the nuclear DNA, after translation it is taged and sent to the mitochondria. UCP1 increases the permeability of the inner mitochondrial membrane to protons, allowing them to move from the inner membrane space to the mitochondrial matrix, bypassing ATP synthase. This process weakens the coupling of the electron transport chain to the production of ATP. In an attempt to raise the pH gradient negatively affected by UCP1, a fast oxidation of substrates occurs while the synthesis rate of ATP stays low and oxidation energy is released as heat instead. UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides. false false _1836_ 0 21307 9 Not in stock false None false Reut Sapir BBa_K1458002_sequence 1 atggggggcctgacagcctcggacgtacacccgaccctgggggtccagctcttctcagctggaatagcggcgtgcttggcggacgtgatcaccttcccgctggacacggccaaagtccggctccaggtccaaggtgaatgcccgacgtccagtgttattaggtataaaggtgtcctgggaacaatcaccgctgtggtaaaaacagaagggcggatgaaactctacagcgggctgcctgcggggcttcagcggcaaatcagctccgcctctctcaggatcggcctctacgacacggtccaggagttcctcaccgcagggaaagaaacagcacctagtttaggaagcaagattttagctggtctaacgactggaggagtggcagtattcattgggcaacccacagaggtcgtgaaagtcagacttcaagcacagagccatctccacggaatcaaacctcgctacacggggacttataatgcgtacagaataatagcaacaaccgaaggcttgacgggtctttggaaagggactactcccaatctgatgagaagtgtcatcatcaattgtacagagctagtaacatatgatctaatgaaggaggcctttgtgaaaaacaacatattagcagatgacgtcccctgccacttggtgtcggctcttatcgctggattttgcgcaacagctatgtcctccccggtggatgtagtaaaaaccagatttattaattctccaccaggacagtacaaaagtgtgcccaactgtgcaatgaaagtgttcactaacgaaggaccaacggctttcttcaaggggttggtaccttccttcttgcgacttggatcctggaacgtcattatgtttgtgtgctttgaacaactgaaacgagaactgtcaaagtcaaggcagactatggactgtgccacataa igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z