BBa_K1470000
1
BBa_K1470000
Ecotropic murine leukemia virus (MuLV) receptor / Cationic amino acid transporter 1 (CAT-1)
2014-10-05T11:00:00Z
2015-05-08T01:10:38Z
We got a plasmid with the DNA for this protein from the AG Brummer at the Institute of Molecular Medicine and Cell Research at the University Freiburg, Germany
The cationic amino acid transporter 1 (CAT-1) is a part of the CAT family which is the main entry gate for amino acids such as histidine, arginine or ornithin in mammalian cells. They enable the influx of their substrate in a Na<up>+</up> independent way and also under certain circumstances the eflux [1].<br>
<h2>Structure and virus recognition</h2><br>
CAT-1 is a 66 kDa membrane protein. It's built up of 622 amino acids contains 14 transmembrane domains. There are two sites for N-glycosylation in the third loop. Also a comparison between CAT-1 sequences from different species shows that region doesn't include conserved amino acids.<br>
The glycosyled position is very important for virus' entry. The murine leukeamia virus is only able to enter the cell, when it detects the SLC7A1's sugar-bound moieties. Otherwise MuLV doesn't infect cells.
false
false
_1849_
0
20909
9
In stock
false
We had none
false
Pascal Sartor
BBa_K1470000_sequence
1
atgggctgcaaaaacctgctcggtctgggccagcagatgctgcgccggaaggtggtggactgtagccgggaggagagccggctgtcccgctgcctcaacacctatgacctggtagctcttggggtgggcagcaccttgggcgctggtgtctatgtcctagccggtgccgtggcccgtgaaaatgctggccctgccatcgtcatctccttcttgattgctgctctcgcctccgtgctggccggcctgtgctacggcgagtttggtgcccgtgtccccaagacgggctcagcctacctctacagctacgtgacggtgggggagctttgggccttcatcactggctggaacctgattctctcctacatcatcggtacttcaagcgtggcaagagcctggagtgcgacttttgacgagctgataggcaagcccatcggagagttctcacgtcagcacatggccctgaatgctcctggggtgctggcccaaaccccggacatatttgctgtgattataattatcatcttaacaggactgttaactcttggcgtgaaggagtcagccatggtcaacaaaattttcacctgtatcaatgtcctggtcttgtgcttcatcgtggtgtccgggttcgtgaaaggctccattaaaaactggcagctcacggagaaaaatttctcctgtaacaacaacgacacaaacgtgaaatacggtgagggagggtttatgccctttggattctctggtgtcctgtcaggggcagcgacctgcttttatgccttcgtgggctttgactgcatcgccaccacaggggaagaagtcaagaacccccagaaggccattcctgtgggcatcgtggcgtccctcctcatttgcttcatagcgtactttggcgtgtccgccgctctcacgctcatgatgccttacttctgcctggacatcgacagcccgctgcctggtgccttcaagcaccagggctgggaagaagctaagtacgcagtggccattggctctctctgcgcactttccaccagtctcctaggctccatgtttcccatgccccgagttatctatgccatggctgaagatggactactgtttaaatttttggccaaaatcaacaataggaccaaaacacccgtaatcgccactgtgacctcaggcgccattgctgctgtgatggccttcctctttgaactgaaggacctggtggacctcatgtccattggcactctcctggcttactctttggtggctgcctgtgttttggtcttacggtaccagccagaacaacctaatctggtataccagatggccagaaccaccgaggagctagatcgagtagatcagaatgagctggtcagtgccagtgaatcacagacaggctttttaccggtagccgagaagttttctctgaaatccatcctctcacccaagaacgtggagccctccaaattctcagggctaattgtgaacatttcagccggcctcctagccgctcttatcatcaccgtgtgcattgtggccgtgcttggaagagaggccctggccgaagggacactgtgggcagtctttgtaatgacagggtcagtcctcctctgcatgctggtgacaggcatcatctggagacagcctgagagcaagaccaagctctcatttaaggtaccctttgtccccgtacttcctgtcttgagcatcttcgtgaacatctatctcatgatgcagctggaccagggcacgtgggtccggtttgcagtgtggatgctgataggtttcaccatctatttcggttatgggatctggcacagtgaggaagcgtccctggctgctggccaggcaaagactcctgacagcaacttggaccagtgcaaatga
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z