BBa_K1641006
1
BBa_K1641006
Fusion protein of Vcre::EGFP::ssra-tag, with RBS at beginning
2015-09-08T11:00:00Z
2015-09-13T10:53:02Z
Vcre from BBa_1641000 (de novo synthesized gene) and EGFP::ssra-tag from pBI121-EGFP is fused by overlap-PCR; others through connection of bricks.
This is a sequence of RBS (BBa_B0034) followed by a fusion protein of Vcre::EGFP::ssra-tag. The part is for expression of Vcre::EGFP::ssra-tag, which aims to overturn our invertase modules in our Micro-timer.
Vcre (BBa_1641000) in our bricks is a new-discovered Cre-like recombinase with invertase activity that turns the sequence between two anti-parallel VloxP sites up-side-down. A EGFP fusion at the C-term of Vcre will not significantly interfere the enzymatic activity. A ssra-tag (BBa_M0051) can accelerate the degradation of the protein, in order to clean it up when not in need and reduce the leakage expression.
false
false
_2058_
24860
20036
9
false
Ssra-Tag is efficiently cleaning the protein when not under induction, and helps to reduce leakage expression. Vcre is according to its structure is similar to Cre, and hence the C-term EGFP fusion tend not to interfere the activity.
false
Pai Li
annotation2447956
1
EGFP::ssra
range2447956
1
1183
1941
annotation2447951
1
B0034
range2447951
1
1
12
annotation2447953
1
Flexible chain
range2447953
1
1159
1182
annotation2447952
1
Vcre
range2447952
1
19
1158
BBa_K1641006_sequence
1
aaagaggagaaaactagaatgattgaaaatcaactgtccctgctgggtgatttttcgggcgttcgtcctgatgacgtgaaaacagccattcaagctgcacagaaaaagggtatcaatgttgcggaaaacgaacagtttaaagccgcgttcgaacatttgctgaacgaatttaaaaagagagaagaacgctactccccaaacaccttgcgtagactggaatcggcctggacttgtttcgttgactggtgcttagccaatcatagacacagcttgcctgcgaccccagatactgtggaagcatttttcattgaacgcgcagaagaactgcatcgtaacacattaagcgtctatagatgggctatcagtcgtgttcacagagtggcaggttgtccagatccgtgcctggacatttacgtggaagatcgcttaaaagccatcgcgagaaaaaaggtccgcgaaggcgaagccgtaaagcaagcgagtccatttaacgaacagcatttattgaaactgacgtccttgtggtatcgctcggataagctgttattgcgccgtaatctggcgctgttagctgtcgcatacgaatctatgttgagagcttcagaactggcaaacattcgcgtatctgatatggaattggccggtgacggcacagcgatcctgacgattccgatcacaaaaacgaatcactcaggtgaacctgatacatgtattctgagccaagacgttgtgagtttgctgatggattatacggaagctggcaaactggatatgtcttcagacggttttctgttcgtcggcgtttctaagcataacacatgcatcaagccaaaaaaggataagcaaacgggtgaagttctgcacaaaccgatcaccactaagaccgtcgaaggcgtattttacagtgcatgggaaactctggacttaggtcgtcagggcgttaaaccgttcaccgctcattccgcaagagtgggtgctgcacaagatttattgaaaaagggctacaacactctgcaaattcaacagtcaggtcgctggagcagtggcgctatggttgcgcgctacggtcgtgctatcttagcacgtgatggcgctatggctcactctcgtgttaaaactagatcagctcctatgcagtggggtaaagatgaaaaggacggagctgatacaggtagcggaggtatggtgagcaagggcgaggagctgttcaccggggtggtgcccatcctggtcgagctggacggcgacgtaaacggccacaagttcagcgtgtccggcgagggcgagggcgatgccacctacggcaagctgaccctgaagttcatctgcaccaccggcaagctgcccgtgccctggcccaccctcgtgaccaccctgacctacggcgtgcagtgcttcagccgctaccccgaccacatgaagcagcacgacttcttcaagtccgccatgcccgaaggctacgtccaggagcgcaccatcttcttcaaggacgacggcaactacaagacccgcgccgaggtgaagttcgagggcgacaccctggtgaaccgcatcgagctgaagggcatcgacttcaaggaggacggcaacatcctggggcacaagctggagtacaactacaacagccacaacgtctatatcatggccgacaagcagaagaacggcatcaaggtgaacttcaagatccgccacaacatcgaggacggcagcgtgcagctcgccgaccactaccagcagaacacccccatcggcgacggccccgtgctgctgcccgacaaccactacctgagcacccagtccgccctgagcaaagaccccaacgagaagcgcgatcacatggtcctgctggagttcgtgaccgccgccgggatcactctcggcatggacgagctgtacaaggctgctaacgacgaaaactacaactacgctgacgcttcttaataa
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z