BBa_K1781001 1 BBa_K1781001 HER2 (Human Epidermal Growth Factor 2) cytoplasmic domain 2015-09-08T11:00:00Z 2015-09-11T01:17:23Z The full HER2 (Human Epidermal Growth Factor 2) protein HER2 is the Human Epidermal Growth Factor 2 transmembrane receptor protein. It is located on all cells and when overexpressed this oncogene is known to induce some types of cancer. In recent years, it has been used as a biomarker. In this project, protein-protein interactions were analyzed and HER2 was identified as a perfect control. Its cytoplasmic tyrosine kinase domain was known to bind to antibodies such as trastuzumab, but more recently the affibody ZHER2 was created to bind to the protein with a higher affinity. In this case, we only needed the cytoplasmic domain for our use in the analysis of the HER2-ZHER2 binding. false false _2206_ 25533 25533 9 false We only needed the cytoplasmic domain, so we had to remove the rest of the protein. false Marvin Prein annotation2448987 1 HER2 range2448987 1 1 600 BBa_K1781001_sequence 1 ataaggaggtactacatggccggcaaccaggaggtgaccgcagaggacggaacccagcgctgtgagaagtgctctaagccgtgtgctagagtgtgctacgggctgggcatggagcacttaagagaggtgcgtgcagtaaccagtgccaatatccaggagttcgcgggctgcaagaagatcttcggttctctggcattcctgcccgagtctttcgacggtgatccagcctcgaacaccgcccccctccagccagagcagctccaggtgttcgagaccctggaagagatcaccgggtatttatacatcagtgcatggcccgattctctgccggatctctctgtatttcagaacctgcaagtaatccgcgggaggatactgcacaatggcgcctattcgctgactctgcaaggtctgggcatctcttggctgggtctgcgttcactgcgtgaactgggctcaggactggccctcatccaccataacacccacctctgctttgtgcacacggtgccgtgggatcagctcttccgcaacccccaccaggcgctgctccacaccgctaaccggccagaggatgagtgtgtgggcgagaccggttaa igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z