BBa_K1781001
1
BBa_K1781001
HER2 (Human Epidermal Growth Factor 2) cytoplasmic domain
2015-09-08T11:00:00Z
2015-09-11T01:17:23Z
The full HER2 (Human Epidermal Growth Factor 2) protein
HER2 is the Human Epidermal Growth Factor 2 transmembrane receptor protein. It is located on all cells and when overexpressed this oncogene is known to induce some types of cancer. In recent years, it has been used as a biomarker. In this project, protein-protein interactions were analyzed and HER2 was identified as a perfect control. Its cytoplasmic tyrosine kinase domain was known to bind to antibodies such as trastuzumab, but more recently the affibody ZHER2 was created to bind to the protein with a higher affinity. In this case, we only needed the cytoplasmic domain for our use in the analysis of the HER2-ZHER2 binding.
false
false
_2206_
25533
25533
9
false
We only needed the cytoplasmic domain, so we had to remove the rest of the protein.
false
Marvin Prein
annotation2448987
1
HER2
range2448987
1
1
600
BBa_K1781001_sequence
1
ataaggaggtactacatggccggcaaccaggaggtgaccgcagaggacggaacccagcgctgtgagaagtgctctaagccgtgtgctagagtgtgctacgggctgggcatggagcacttaagagaggtgcgtgcagtaaccagtgccaatatccaggagttcgcgggctgcaagaagatcttcggttctctggcattcctgcccgagtctttcgacggtgatccagcctcgaacaccgcccccctccagccagagcagctccaggtgttcgagaccctggaagagatcaccgggtatttatacatcagtgcatggcccgattctctgccggatctctctgtatttcagaacctgcaagtaatccgcgggaggatactgcacaatggcgcctattcgctgactctgcaaggtctgggcatctcttggctgggtctgcgttcactgcgtgaactgggctcaggactggccctcatccaccataacacccacctctgctttgtgcacacggtgccgtgggatcagctcttccgcaacccccaccaggcgctgctccacaccgctaaccggccagaggatgagtgtgtgggcgagaccggttaa
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z