BBa_K1808001 1 BBa_K1808001 ALDH1 from Artemisia annua 2015-09-15T11:00:00Z 2015-09-16T10:10:26Z Artemisia annua This is the coding region of the ALDH1 gene from Artemisia annua with added biobrick suffix and prefix in a pSB1C3 plasmid backbone. This part is an element of TCD iGEM 2015 set of parts for the synthesis of the anti-malarial drug precursor dihydroartemisinic acid in E. coli. The ALDH1 gene encodes the enzyme aldehyde dehydrogenase 1, which catalyses the conversion of (11R)-dihydroartemisinic aldehyde to dihydroartemisinic acid as well as the conversion of artemisinic aldehyde to artemisinic acid with NADP+ as the substrate. Artemisinic acid and dihydroartemisinic acid can be extracted from E. coli cells through lysis and chemically converted to the anti-malarial artemisinin. This part is codon optimised for BioBrick 3A assembly and expression in E. coli cells. false false _2233_ 26113 26113 9 false This part is Biobrick 3A assembly, expression in E. coli and synthesis codon optimised. false Arnas Petrauskas annotation2461086 1 ALDH1 range2461086 1 1 1500 BBa_K1808001_sequence 1 atgtcttctggtgcgaacggttcttctaaatctgcgtctcacaaaatcaaattcaccaaactgttcatcaacggtgaatttgttgactctatctctggtaacaccttcgacaccatcaacccggcgaccgaagaagttctggcgaccgttgcggaaggtcgtaaagaagacatcgacctggcggttaaagcggcgcgtgaagcgttcgacaacggtccgtggccgcgtatgtctggtgaagcgcgtcgtaaaatcatgctgaaattcgcggacctgatcgacgaaaacgcggacgaactgaccaccctggaagttatcgacggtggtaaactgttcggtccggttcgtcacttcgaagttccggtttcttctgacaccttccgttacttcgcgggtgcggcggacaaaatccgtggtgcgaccctgaaaatgtcttctaacatccaggcgtacaccctgcgtgaaccgatcggtgttgttggtcacatcatcccgtggaacggtccggcgttcatgttcgcgaccaaagttgctccggcgctggcggcgggttgcaccatggttatcaaaccggcggaacacaccccgctgaccgttctgttcctggcgcacctgtctaaactggcgggtgttccggacggtgttatcaacgttgttaacggtttcggtaaaaccgcgggtgcggcggtttcttctcacatggacatcgacatggttaccttcaccggctctaccgaagttggtcgtaccgttatgcaggcggcggcgctgtctaacctgaagccggtttctctggaactgggtggtaaatctccgctgatcgttttcgacgacgcggacgttgacaaagcggcggaatttgcgatcctgggtaacttcaccaacaaaggtgaaatgtgcgttgcgggttctcgtgttttcgttcaggaaggtatccacgacgttttcgttaaaaaactggaaggtgcggttaaagcgtgggcgacccgtgacccgttcgacctggcgacccgtcacggtccgcagaacaacaaacagcagtacgacaaagttctgtcttgcatcaaccacggtaaaaaagaaggtgcgaccctggttaccggcggtaaaccgttcggtaaaaaaggttactacatcgaaccgaccctgttcaccaacgttaccgacgacatgaccatcgcgaaagaagaaatcttcggtccggttatctctgttctgaaattcaaaaccgttgaagaagttatcaaacgtgcgaacgcgaccaaatacggtctggcgtctggtgttttcaccaaaaacatcgacgttgttaacaccgtttctcgttctatccgtgcgggtgcggtttgggttaactgctacctggcgctggaccgtgacgcgccgcacggtggttacaaaatgtctggtttcggtcgtgaacagggtctggaagcgctggaacactacctgcaaatcaaaaccgttgcgaccccgatctacgactctccgtggctgtaa igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z