BBa_K1922003 1 BBa_K1922003 wild type P53 2016-10-10T11:00:00Z 2016-10-14T11:10:36Z This gene is from genomic sequence. P53 is a generally acknowledged tumor surpressing gene.This gene can hold tumor cell in G0phase, therefore stop cell proliferation. false false _2389_ 29295 29878 9 false P53 is reported playing an vital role in tumor heat treatment. During heated ,P53 can start downstream protein expression as a heat sensor.In brief,it detects heat signals and starts cell apoptosis. false Jiawei Zhang BBa_K1922010 1 BBa_K1922010 luciferase 2016-10-13T11:00:00Z 2016-10-14T11:06:09Z luciferase comes from genomic sequences of Methanocella conradii.. After inserting the HSP70-p53 fraction into pGL3 vector which contains a luciferase gene, we could obeserve if the tumor cells had been heat treated at in vivo bioluminescence imaging machine with the injection of luciferase substance. false false _2389_ 29295 29295 9 false It will be used to build composite part(hsp70-p53-luciferase) false WANG HONGNING BBa_K1922012 1 BBa_K1922012 hsp70-p53-luciferase 2016-10-13T11:00:00Z 2016-10-14T11:12:39Z It comes from specific genomic sequence of our submitted basic parts. Heat shock protein 70 will be synthesized rapidly after heat shock, while conventional thermotherapy has already got great efficiency in clinical application, we wonder if we can make the whole system responsive, which means there can be a reporter system telling people that heat treatment of laser is working. HSP70 promoter can drive the transcription of p53 gene after heat shock which is done by laser and AuNRs. false false _2389_ 29295 29295 9 true It will optimize the efficiency of heat treatment. false WANG HONGNING component2507184 1 BBa_K1922004 component2507186 1 BBa_K1922010 component2507185 1 BBa_K1922003 annotation2507184 1 BBa_K1922004 range2507184 1 1 477 annotation2507186 1 BBa_K1922010 range2507186 1 1674 2666 annotation2507185 1 BBa_K1922003 range2507185 1 484 1665 BBa_K1922004 1 BBa_K1922004 HSP promoter 2016-10-10T11:00:00Z 2016-10-14T01:17:46Z This part comes from genomic sequence. the hsp also known as heat shook protein, is a protein expressed only when the cell detected some change from temperature.The Hsp promoter can start downstream gene expression when heated. false false _2389_ 29295 29878 9 No part sequence false This promoter can work as a heat sensor. false Jiawei Zhang BBa_K1922010_sequence 1 gtgaagacgaaaatcggatatttcgcatcattggaacaatataagccaatggatgcgctaacacagtctgtaagggcagagagcgtgggttttgactcgatctgggtggacgaccacttccatccatggtatcacactggcgcgcagagtgcccaggcatgggcctggatgggtgcaacgctacaggcaacgaagcgcgtgtttatttccacgtgtatcacctgtccgatcattcgctacaaccccgcagtcgtggctcagacattcgccacgctgaggcaaatgtaccctggcagggtaggcgtcgcggtcggagctggcgaggcgatgaacgaggtccctgtcacgggtcaatggccatccgtgcccgagaggcaggatatgaccgtcgaggccgttcaggtcatgcagaagttatgggagagcaaagagccggtgacgttcaaagggaagtattataccctagataaggcgttcctgtatactaagccgattgataaagtgcccatttacttcagcggcatgggacagaaaggcgccaggctagccggtaaatacggcgaccacctgatgaccgtcgccgcagacccggcaacgctgaaaaacgtaactattccgcagtttgaggctggggccagggaagcgggaaaagacccgagtaagatggaacgcgcgatgctgatctggtattcagtggatccggactatgaaaaggcgatcgaaggccttcgcttctgggccggatgcctggtcccggcaatgttcaagtacaaagtctatgactcgaaggaagtcgaactgcacgcgaacatagtcggccatgacatgattaagaacaactacatggtggcgactaacgccgaagatctgataaaggagatcaagcggttcaagaacgccggcatcacgcacttctgcctcgggaacagcagccccaacgtcaatgcagggatagacatattcaaggatgtcattccggcagtaaaagagtga BBa_K1922004_sequence 1 acgcgtgtgcagggccgcccactcccccttcctctcagggtccctgtcccctccagtgaatcccagaagactctggagagttctgagcagggggcggcactctggcctctgattggtccaaggaaggctggggggcaggacgggaggcgaaaaccctggaatattcccgacctggcagcctcatcgagctcggtgattggctcagaagggaaaaggcgggtctccgtgacgacttataaaagcccaggggcaagcggtccggataacggctagcctgaggagctgctgcgacagtccactacctttttcgagagtgactcccgttgtcccaaggcttcccagagcgaacctgtgcgggtgcaggcaccggcgcgtcgagtttccggcgtccggaaggaccgagctcttctcgcggatccagtgttccgtttccagcccccaatctcagagcggagccgacagagagcagggaacccgccaccatggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttcagacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatggatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtccagatgaagctcccagaatgccagaggctgctccccgcgtggcccctgcaccagcagctcctacaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccagaaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaagtctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacctgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatggccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgagcgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaatttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctatgagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagttcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactccagtggtaatctactgggacggaacagctttgaggtgcatgtttgtgcctgtcctgggagagaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgcccccagggagcactaagcgagcactgtccaacaacaccagctcctctccccagccaaagaagaaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatgttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggggggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccataaaaaactcatgttcaagacagaagggcctgactcagacaagctt BBa_K1922012_sequence 1 acgcgtcctgcagggccgcccactcccccttcctctcagggtccctgtcccctccagtgaatcccagaagactctggagagttctgagcagggggcggcactctggcctctgattggtccaaggaaggctggggggcaggacgggaggcgaaaaccctggaatattcccgacctggcagcctcatcgagctcggtgattggctcagaagggaaaaggcgggtctccgtgacgacttataaaagcccaggggcaagcggtccggataacggctagcctgaggagctgctgcgacagtccactacctttttcgagagtgactcccgttgtcccaaggcttcccagagcgaacctgtgcggctgcaggcaccggcgcgtcgagtttccggcgtccggaaggaccgagctcttctcgcggatccagtgttccgtttccagcccccaatctcagagcggagccgacagagagcagggaaccctactagatggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttcagacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatggatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtccagatgaagctcccagaatgccagaggctgctccccgcgtggcccctgcaccagcagctcctacaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccagaaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaagtctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacctgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatggccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgagcgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaatttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctatgagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagttcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactccagtggtaatctactgggacggaacagctttgaggtgcatgtttgtgcctgtcctgggagagaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgcccccagggagcactaagcgagcactgtccaacaacaccagctcctctccccagccaaagaagaaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatgttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggggggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccataaaaaactcatgttcaagacagaagggcctgactcagactgatactagaggtgaagacgaaaatcggatatttcgcatcattggaacaatataagccaatggatgcgctaacacagtctgtaagggcagagagcgtgggttttgactcgatctgggtggacgaccacttccatccatggtatcacactggcgcgcagagtgcccaggcatgggcctggatgggtgcaacgctacaggcaacgaagcgcgtgtttatttccacgtgtatcacctgtccgatcattcgctacaaccccgcagtcgtggctcagacattcgccacgctgaggcaaatgtaccctggcagggtaggcgtcgcggtcggagctggcgaggcgatgaacgaggtccctgtcacgggtcaatggccatccgtgcccgagaggcaggatatgaccgtcgaggccgttcaggtcatgcagaagttatgggagagcaaagagccggtgacgttcaaagggaagtattataccctagataaggcgttcctgtatactaagccgattgataaagtgcccatttacttcagcggcatgggacagaaaggcgccaggctagccggtaaatacggcgaccacctgatgaccgtcgccgcagacccggcaacgctgaaaaacgtaactattccgcagtttgaggctggggccagggaagcgggaaaagacccgagtaagatggaacgcgcgatgctgatctggtattcagtggatccggactatgaaaaggcgatcgaaggccttcgcttctgggccggatgcctggtcccggcaatgttcaagtacaaagtctatgactcgaaggaagtcgaactgcacgcgaacatagtcggccatgacatgattaagaacaactacatggtggcgactaacgccgaagatctgataaaggagatcaagcggttcaagaacgccggcatcacgcacttctgcctcgggaacagcagccccaacgtcaatgcagggatagacatattcaaggatgtcattccggcagtaaaagagtga BBa_K1922003_sequence 1 atggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttcagacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatggatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtccagatgaagctcccagaatgccagaggctgctccccgcgtggcccctgcaccagcagctcctacaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccagaaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaagtctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacctgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatggccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgagcgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaatttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctatgagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagttcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactccagtggtaatctactgggacggaacagctttgaggtgcatgtttgtgcctgtcctgggagagaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgcccccagggagcactaagcgagcactgtccaacaacaccagctcctctccccagccaaagaagaaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatgttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggggggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccataaaaaactcatgttcaagacagaagggcctgactcagactga igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z