BBa_K1940000 1 BBa_K1940000 anti-microRNA-34c 2016-10-10T11:00:00Z 2016-10-13T09:32:59Z Homo sapiens (human),Chromosome 11, NC_000011.10 (111513439..111513515) Anti- microRNA-34c can be used as a miR-34c detector. MiR-34c is significantly upregulated in Alzheimer's disease (AD) patients. Several researches have suggested that strategies to manipulate miR-34c could open a suitable novel virus-free therapeutic avenue to treat cognitive diseases. In this part, we designed 4 series antisense strand of miR-34c which are linked by 4 linkers. Anti- microRNA-34c is sensitive to the expression levels of miR-34c. And combined with a reporter, we can diagnose AD accurately and rapidly. false false _2407_ 30070 30070 9 true 4 copies of anti-microRNA-34c can enhance the detection sensitivity. false Yujia Liu annotation2492777 1 anti-microRNA-34c range2492777 1 80 102 annotation2492776 1 anti-microRNA-34c range2492776 1 50 72 annotation2492782 1 linker range2492782 1 43 49 annotation2492781 1 linker range2492781 1 73 79 annotation2492784 1 linker range2492784 1 103 109 annotation2492763 1 anti-microRNA-34c range2492763 1 20 42 annotation2492780 1 anti-microRNA-34c range2492780 1 110 132 BBa_K1940000_sequence 1 aagcttggtctcgctagaggcaatcagctaactacactgcctgggtcccgcaatcagctaactacactgcctgggtcccgcaatcagctaactacactgcctgggtcccgcaatcagctaactacactgccttactagcgagaccggtacc igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 James Alastair McLaughlin Chris J. Myers 2017-03-06T15:00:00.000Z