BBa_K2020042
1
BBa_K2020042
Mj-tRNA with amber anticodon for incorporating ncAA in E.coli
2016-10-01T11:00:00Z
2016-10-16T04:54:27Z
wild type tyrosyl Methanococcus janaschii tRNA:Synthetase-pair with anticodon changed to Amber Anticodon CTA
For incorporating unnatural amino acids into a protein, a orthogonal tRNA:Synthetase-pair is needed. This tRNA derives from wild type tyrosyl Methanococcus janaschii tRNA:Synthetase pair. It is used together with a tRNA-Synthetase in E.coli. The tRNA has an amber anticodon for incorporating the ncAA in response to an amber codon. It has been proven to work with (enter links for parts) wild type Y-RS, AzF-RS, CNF-RS, Iodo-Y-RS, 5HTP-RS, Nitro-Y-RS by iGEM-Team Texas 2014 (Link).
false
false
_2487_
29923
29923
9
true
Since tRNA and Synthetases have own promotors and since they are frequently used in low copy plasmids, you should assemble tRNA and Syntehtases on a plasmid (e.g. pACYC) which fits your needs.
Team Aachen 2016 ( http://2016.igem.org/Team:Aachen ) used tRNA in pACYC with p15A-ORI, Ipp-Promoter, Gent-Resistance. Together with an ncAA-Synthetase (For example: BBa_K2020050) with own promoter.
false
Andrea Hoeltken, Vroni Czotscher, Carolina Bonerath
annotation2485610
1
tRNA
range2485610
1
1
77
BBa_K2020042_sequence
1
ccggcggtagttcagcagggcagaacggcggactctaaatccgcaggtcgctggttcaaatccggcccgccggacca
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z