BBa_K2128004
1
BBa_K2128004
HDLEA1
2016-08-12T11:00:00Z
2016-10-21T02:46:43Z
Ramazzottius varieornatus
This part is a member is a class of intrinsically disordered proteins called the Late Embryonic Abundant (LEA) proteins that become ordered when desiccated, thereby stabilizing DNA and protein cell components. This tardigrade unique protein is found in the mitochondria of tardigrade cells. When cloned into humans, they confer protection against osmotic stress as shown in the paper "Novel Mitochondria-Targeted Heat-Soluble Proteins Identified in the Anhydrobiotic Tardigrade Improve Osmotic Tolerance of Human Cells" by Sae Tanaka et al. 2015 Feb 12.
It was taken from the genome of Ramazzottius varieornatus and optimized by the IDT Codon Optimization Tool for E. Coli K12.
false
false
_2597_
32302
32302
9
true
This part was optimized by the IDT Codon Optimization Tool for E. Coli K12.
false
David Sanderson
annotation2481454
1
HDLEA1_ORF
range2481454
1
1
272
BBa_K2128004_sequence
1
atgtcgcccgcagataagaaatgggaggatgcaaaagaggaaggttccgcagcgttcaaggatgcaaaggacgctgcatccttaaaggcaggtgagctgcgcgatagtgccagtcaaaaggccagccagttacgtgatagcagtatccagaaagcgagcgaactggaggattcggcagtacaaaagggatataatctggataagtctgctaacgaaacgatcagtaacgccaaagaggcagttgatcgcaaggtggaacagggaaaaagtagc
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z