BBa_K258010 1 BBa_K258010 Human Epidermal growth factor (hEGF) 2009-10-09T11:00:00Z 2015-05-08T01:11:42Z EGF is synthesized in human and some mammalians. Our EGF was synthesized synthetically at GENEART Epidermal growth factor (EGF) is a single chain, 53 aminoacid-residue polypeptide (molecular weight 6045) and three intramolecular disulfide bonds. EGF is a low-molecular-weight polypeptide first purified from the mouse submandibular gland, but since then found in many human tissues including submandibular gland, parotid gland. EGF results in cellular proliferation, differentiation, and survival. EGF stimulates the growth of skin and corneal epithelium in vivo and in organ cultures. Epidermal growth factor (EGF) stimulates the growth of keratinocytes in vivo, and therefore plays an important role in the process of wound healing that depends on mitosis and migration of keratinocytes. Rhinewald and Green showed, in vitro that in the presence of growth factors , higher percentage of cells leave the resting state, enter and remain in the mitotic cycle. Mitogenic effect of EGF requires continuous exposure of target cells to EGF for a minimum 6-12 hours. The stimulation of wound healing by EGF has been confirmed as growth of granulation tissue in sponge implants used as inductive matrices. They observed, in rats, dose-dependent effect of EGF on granulation tissue formation as increased amounts of nucleic acids, and accumulation of collagen and glycosaminoglycans. false false _358_ 0 4260 9 It's complicated true EGF with Biobrick standart restriction sites false Cihan Tastan and Ozkan IS BBa_K258010_sequence 1 atgaacagcgactcggagtgtccactgtcacatgatggctattgcctgcacgatggcgtttgtatgtatatcgaggccctggacaaatatgcctgtaactgtgtggtgggctatatcggtgaacgttgccagtatcgtgacctgaaatggtgggaactgcgt igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z