BBa_K976002 1 BBa_K976002 FGFR-1 + FRS2 Complex 2013-06-19T11:00:00Z 2015-05-08T01:13:49Z The FGFR-1 protein sequence has been derived from the Emblem Database. The FRS2 protein sequence has been derived from the UnitProt Database. The Fibroblast Growth Factor Receptor-1 and Fibroblast Growth Factor Receptor Substrate 2 complex comprises a fusion protein complex that has the capability to mediate signal transduction. In melanocytes, this multi-protein complex mediate signal transduction to such pathways as the MAPK pathway, which regulate melanocyte proliferation, migration, and differentiation. false false _1269_ 0 15167 9 Not in stock false No specific design considerations were dealt with. false Amna Sohail component2329799 1 BBa_K976000 component2329800 1 BBa_K976001 annotation2329800 1 BBa_K976001 range2329800 1 2473 3996 annotation2329799 1 BBa_K976000 range2329799 1 1 2466 BBa_K976001 1 FRS2 Fibroblast Growth Factor Receptor Substrate 2 2013-06-19T11:00:00Z 2015-05-08T01:13:49Z Source: UniProt Database Organism: Homo sapiens The Fibroblast Growth Factor Receptor Substrate 2, or FRS2 protein is a lipid based membrane-anchored docking protein that forms a fusion protein complex with the Fibroblast Growth Factor Receptor-1 (FGFR-1) to regulate downstream signal transduction. In melanocytes, this docking protein mediates signal transduction to pathways as the MAPK pathway that are involved in melanocyte proliferation, differentiation, and migration. FRS2 may be useful in its ability to mediate downstream signaling as the FGF2 ligand binds to FGFR-1. false false _1269_ 0 15167 9 Not in stock false No particular design considerations were dealt with. false Amna Sohail BBa_K976000 1 FGFR-1 Fibroblast Growth Factor-1 Receptor Coding Sequence 2013-06-09T11:00:00Z 2015-05-08T01:13:49Z The part has been derived from a genomic sequence provisioned by the Ensembl Database. The Fibroblast Growth Factor-1 Receptor (FGFR-1) is a receptor that is commonly found in melanocytes and is involved with melanocyte differentiation, migration, and division. Malignant melanoma is characterized by abnormally high ligand expression of Fibroblast Growth Factor-2 (FGF2), otherwise known as the Basic Fibroblast Growth Factor (BFGF). The FGFR-1 receptor as a high affinity towards binding to the FGF2 ligand present upon the surface of potentially malignant melanocytes, and therefore may be utilized to detect presence of malignant melanoma tumor. false false _1269_ 0 15167 9 Not in stock false The start codon sequence has been added to the FGFR-1 coding sequence. false Amna Sohail annotation2329993 1 Ig-like C2-type 3 Domain range2329993 1 765 1071 annotation2329945 1 Cytoplasmic Domain range2329945 1 1194 2466 annotation2329943 1 Topological Extracellular Domain range2329943 1 66 1128 annotation2329947 1 Ig-like C2-type 2 Domain range2329947 1 474 738 annotation2329944 1 Helical Transmembrane Domain range2329944 1 1131 1191 annotation2329946 1 Ig-like C2-type 1 Domain range2329946 1 75 357 annotation2329994 1 Protein Kinase Domain range2329994 1 1434 2301 BBa_K976002_sequence 1 atgtggtcctggaaatgtttgttgttttgggcggtcttggtcaccgcgaccttgtgtaccgcgcgtccttcccctaccttgcctgagcaagcgcaaccttggggggcgcctgtcgaggtcgagtcctttttggtccatcctggggacttgttgcaattgcgttgtcgtttgcgtgacgacgtccaatccatcaactggttgcgtgacggggtccaattggcggagtccaaccgtacccgtatcaccggggaggaggtcgaggtccaagactccgtccctgcggactccgggttgtatgcgtgtgtcacctcctccccttccgggtccgacaccacctatttttccgtcaacgtctccgacgcgttgccttcctccgaggacgacgacgacgacgacgactcctcctccgaggagaaagaaaccgacaacaccaaacctaaccgtatgcctgtcgcgccttattggacctcccctgagaaaatggagaaaaaattgcatgcggtccctgcggcgaaaaccgtcaaatttaaatgtccttcctccgggacccctaaccctaccttgcgttggttgaaaaacgggaaagagtttaaacctgaccatcgtatcggggggtataaagtccgttatgcgacctggtccatcatcatggactccgtcgtcccttccgacaaagggaactatacctgtatcgtcgagaacgagtatgggtccatcaaccatacctatcaattggacgtcgtcgagcgttcccctcatcgtcctatcttgcaagcggggttgcctgcgaacaaaaccgtcgcgttggggtccaacgtcgagtttatgtgtaaagtctattccgaccctcaacctcatatccaatggttgaaacatatcgaggtcaacgggtccaaaatcgggcctgacaacttgccttatgtccaaatcttgaaaaccgcgggggtcaacaccaccgacaaagagatggaggtcttgcatttgcgtaacgtctcctttgaggacgcgggggagtatacctgtttggcggggaactccatcgggttgtcccatcattccgcgtggttgaccgtcttggaggcgttggaggagcgtcctgcggtcatgacctcccctttgtatttggagatcatcatctattgtaccggggcgtttttgatctcctgtatggtcgagtccgtcatcgtctataaaatgaaatccgggaccaaaaaatccgactttcattcccaaatggcggtccataaattggcgaaatccatccctttgcgtcgtcaagtcaccgtctccgcggactcctccgcgtccatgaactccggggtcttgttggtccgtccttcccgtttgtcctcctccgggacccctatgttggcgggagtctccgagtatgagttgcctgaggaccctcgttgggagttgcctcgtgaccgtttggtcttggggaaacctttgggggaggggtgttttgggcaagtcgtcttggcggaggcgatcgggttggacaaagacaaacctaaccgtgtcaccaaagtcgcggtcaaaatgttgaaatccgacgcgaccgagaaagacttgtccgacttgatctccgagatggagatgatgaaaatgatcgggaaacataaaaacatcatcaacttgttgggggcgtgtacccaagacgggcctttgtatgtcatcgtcgagtatgcgtccaaagggaacttgcgtgagtatttgcaagcgcgtcgtcctcctgggttggagtattgttataacccttcccataaccctgaggagcaattgtcctccaaagacttagtctcctgtgcgtatcaagtcgcgcgtgggatggagtatttggcgtccaaaaaatgtatccatcgtgacttggcggcgcgtaacgtcttggtcaccgaggacaacgtcatgaaaatcgcggactttgggttggcgcgtgacatccatcatatcgactattataaaaaaaccaccaacgggcgtttgcctgtcaaatggatggcgcctgaggcgttgtttgaccgtatctatacccatcaatccgacgtctggtcctttggggtcttgttgtgggaaatctttaccttgggggggtccccttatcctggggtccctgtcgaggagttgtttaaattgttgaaagaggggcatcgtatggacaaaccttccaactgtaccaacgagttgtatatgatgatgcgtgactgttggcatgcggtcccttcccaacgtcctacctttaaacaattggtcgaggacttggaccgtatcgtcgcgttgacctccaaccaagagtatttggacttgtccatgcctttggaccaatattccccttcctttcctgacacccgttcctccacctgttcctccggggaggactccgtcttttcccatgagcctttgcctgaggagccttgtttgcctcgtcatcctgcgcaattggcgaacggggggttgaaacgtcgttactagatggggtcctgttgttcctgtcctgacaaagacaccgtccctgacaaccatcgtaacaaatttaaagtcatcaacgtcgacgacgacgggaacgagttggggtccgggatcatggagttgaccgacaccgagttgatcttgtatacccgtaaacgtgactccgtcaaatggcattatttgtgtttgcgtcgttatgggtatgactccaacttgttttcctttgagtccgggcgtcgttgtcaaaccgggcaagggatctttgcgtttaaatgtgcgcgtgcggaggagttgtttaacatgttgcaagagatcatgcaaaacaactccatcaacgtcgtcgaggagcctgtcgtcgagcgtaacaaccatcaaaccgagttggaggtccctcgtacccctcgtacccctaccacccctgggtttgcggcgcaaaacttgcctaacgggtatcctcgttatccttcctttggggacgcgtcctcccatccttcctcccgtcatccttccgtcgggtccgcgcgtttgccttccgtcggggaggagtccacccatcctttgttggtcgcggaggagcaagtccatacctatgtcaacaccaccggggtccaagaggagcgtaaaaaccgtacctccgtccatgtccctttggaggcgcgtgtctccaacgcggagtcctccacccctaaagaggagccttcctccatcgaggaccgtgaccctcaaatcttgttggagcctgagggggtcaaatttgtcttggggcctacccctgtccaaaaacaattgatggagaaagagaaattggagcaattggggcgtgaccaagtctccgggtccggggcgaacaacaccgagtgggacaccgggtatgactccgacgagcgtcgtgacgcgccttccgtcaacaaattggtctatgagaacatcaacgggttgtccatcccttccgcgtccggggtccgtcgtgggcgtttgacctccacctccacctccgacacccaaaacatcaacaactccgcgcaacgtcgtaccgcgttgttgaactatgagaacttgccttccttgcctcctgtctgggaggcgcgtaaattgtcccgtgacgaggacgacaacttggggcctaaaaccccttccttgaacgggtatcataacaacttggaccctatgcataactatgtcaacaccgagaacgtcaccgtccctgcgtccgcgcataaaatcgagtattcccgtcgtcgtgactgtacccctaccgtctttaactttgacatccgtcgtccttccttggagcatcgtcaattgaactatatccaagtcgacttggagggggggtccgactccgacaaccctcaaacccctaaaacccctaccacccctttgcctcaaacccctttgcgtcgtaccgagttgtatgcggtcatcgacatcgagcgtaccgcggcgatgtccaacttgcaaaaagcgttgcctcgtgacgacgggacctcccgtaaaacccgtcataactccaccgacttgcctatg BBa_K976001_sequence 1 atggggtcctgttgttcctgtcctgacaaagacaccgtccctgacaaccatcgtaacaaatttaaagtcatcaacgtcgacgacgacgggaacgagttggggtccgggatcatggagttgaccgacaccgagttgatcttgtatacccgtaaacgtgactccgtcaaatggcattatttgtgtttgcgtcgttatgggtatgactccaacttgttttcctttgagtccgggcgtcgttgtcaaaccgggcaagggatctttgcgtttaaatgtgcgcgtgcggaggagttgtttaacatgttgcaagagatcatgcaaaacaactccatcaacgtcgtcgaggagcctgtcgtcgagcgtaacaaccatcaaaccgagttggaggtccctcgtacccctcgtacccctaccacccctgggtttgcggcgcaaaacttgcctaacgggtatcctcgttatccttcctttggggacgcgtcctcccatccttcctcccgtcatccttccgtcgggtccgcgcgtttgccttccgtcggggaggagtccacccatcctttgttggtcgcggaggagcaagtccatacctatgtcaacaccaccggggtccaagaggagcgtaaaaaccgtacctccgtccatgtccctttggaggcgcgtgtctccaacgcggagtcctccacccctaaagaggagccttcctccatcgaggaccgtgaccctcaaatcttgttggagcctgagggggtcaaatttgtcttggggcctacccctgtccaaaaacaattgatggagaaagagaaattggagcaattggggcgtgaccaagtctccgggtccggggcgaacaacaccgagtgggacaccgggtatgactccgacgagcgtcgtgacgcgccttccgtcaacaaattggtctatgagaacatcaacgggttgtccatcccttccgcgtccggggtccgtcgtgggcgtttgacctccacctccacctccgacacccaaaacatcaacaactccgcgcaacgtcgtaccgcgttgttgaactatgagaacttgccttccttgcctcctgtctgggaggcgcgtaaattgtcccgtgacgaggacgacaacttggggcctaaaaccccttccttgaacgggtatcataacaacttggaccctatgcataactatgtcaacaccgagaacgtcaccgtccctgcgtccgcgcataaaatcgagtattcccgtcgtcgtgactgtacccctaccgtctttaactttgacatccgtcgtccttccttggagcatcgtcaattgaactatatccaagtcgacttggagggggggtccgactccgacaaccctcaaacccctaaaacccctaccacccctttgcctcaaacccctttgcgtcgtaccgagttgtatgcggtcatcgacatcgagcgtaccgcggcgatgtccaacttgcaaaaagcgttgcctcgtgacgacgggacctcccgtaaaacccgtcataactccaccgacttgcctatg BBa_K976000_sequence 1 atgtggtcctggaaatgtttgttgttttgggcggtcttggtcaccgcgaccttgtgtaccgcgcgtccttcccctaccttgcctgagcaagcgcaaccttggggggcgcctgtcgaggtcgagtcctttttggtccatcctggggacttgttgcaattgcgttgtcgtttgcgtgacgacgtccaatccatcaactggttgcgtgacggggtccaattggcggagtccaaccgtacccgtatcaccggggaggaggtcgaggtccaagactccgtccctgcggactccgggttgtatgcgtgtgtcacctcctccccttccgggtccgacaccacctatttttccgtcaacgtctccgacgcgttgccttcctccgaggacgacgacgacgacgacgactcctcctccgaggagaaagaaaccgacaacaccaaacctaaccgtatgcctgtcgcgccttattggacctcccctgagaaaatggagaaaaaattgcatgcggtccctgcggcgaaaaccgtcaaatttaaatgtccttcctccgggacccctaaccctaccttgcgttggttgaaaaacgggaaagagtttaaacctgaccatcgtatcggggggtataaagtccgttatgcgacctggtccatcatcatggactccgtcgtcccttccgacaaagggaactatacctgtatcgtcgagaacgagtatgggtccatcaaccatacctatcaattggacgtcgtcgagcgttcccctcatcgtcctatcttgcaagcggggttgcctgcgaacaaaaccgtcgcgttggggtccaacgtcgagtttatgtgtaaagtctattccgaccctcaacctcatatccaatggttgaaacatatcgaggtcaacgggtccaaaatcgggcctgacaacttgccttatgtccaaatcttgaaaaccgcgggggtcaacaccaccgacaaagagatggaggtcttgcatttgcgtaacgtctcctttgaggacgcgggggagtatacctgtttggcggggaactccatcgggttgtcccatcattccgcgtggttgaccgtcttggaggcgttggaggagcgtcctgcggtcatgacctcccctttgtatttggagatcatcatctattgtaccggggcgtttttgatctcctgtatggtcgagtccgtcatcgtctataaaatgaaatccgggaccaaaaaatccgactttcattcccaaatggcggtccataaattggcgaaatccatccctttgcgtcgtcaagtcaccgtctccgcggactcctccgcgtccatgaactccggggtcttgttggtccgtccttcccgtttgtcctcctccgggacccctatgttggcgggagtctccgagtatgagttgcctgaggaccctcgttgggagttgcctcgtgaccgtttggtcttggggaaacctttgggggaggggtgttttgggcaagtcgtcttggcggaggcgatcgggttggacaaagacaaacctaaccgtgtcaccaaagtcgcggtcaaaatgttgaaatccgacgcgaccgagaaagacttgtccgacttgatctccgagatggagatgatgaaaatgatcgggaaacataaaaacatcatcaacttgttgggggcgtgtacccaagacgggcctttgtatgtcatcgtcgagtatgcgtccaaagggaacttgcgtgagtatttgcaagcgcgtcgtcctcctgggttggagtattgttataacccttcccataaccctgaggagcaattgtcctccaaagacttagtctcctgtgcgtatcaagtcgcgcgtgggatggagtatttggcgtccaaaaaatgtatccatcgtgacttggcggcgcgtaacgtcttggtcaccgaggacaacgtcatgaaaatcgcggactttgggttggcgcgtgacatccatcatatcgactattataaaaaaaccaccaacgggcgtttgcctgtcaaatggatggcgcctgaggcgttgtttgaccgtatctatacccatcaatccgacgtctggtcctttggggtcttgttgtgggaaatctttaccttgggggggtccccttatcctggggtccctgtcgaggagttgtttaaattgttgaaagaggggcatcgtatggacaaaccttccaactgtaccaacgagttgtatatgatgatgcgtgactgttggcatgcggtcccttcccaacgtcctacctttaaacaattggtcgaggacttggaccgtatcgtcgcgttgacctccaaccaagagtatttggacttgtccatgcctttggaccaatattccccttcctttcctgacacccgttcctccacctgttcctccggggaggactccgtcttttcccatgagcctttgcctgaggagccttgtttgcctcgtcatcctgcgcaattggcgaacggggggttgaaacgtcgt igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z