BBa_M12072
1
BBa_M12072
CueR internal copper sensor
2010-05-11T11:00:00Z
2015-05-08T01:13:55Z
Yersinia pseudotuberculosis genome. http://www.ncbi.nlm.nih.gov/gene/2955378
Information on function from
JL Hobman, J Wilkie, NL Brown. "A design for life: prokaryotic metal-binding MerR family regulators." Biometals, 2005.
http://www.springerlink.com/content/u7732202161l4847/
CueR is a copper-sensitive activator/repressor found in Yersinia pseudotuberculosis which performs a task for copper similar to that performed by merR for mercury. In absence of copper, it represses the transcription of the genes downstream of it (in source, cueTPAD), but when bound to copper it causes underwinding of cueOP DNA and thus promotes RNA polymerase transcription of the region. In the source genome, the following sequences are copper coping mechanisms.
Any genes inserted downstream of cueR will be transcribed only in the presence of copper inside the cell. Usable in E. coli and various other bacteria.
false
false
_548_
0
6722
9
Not in stock
false
none
false
Will Whitney
BBa_M12072_sequence
1
atgaacattagcgatgttgcgaaaaaaaccggtttaaccagcaaagccattcgtttttatgaagaaaaaaaactggtgacgccacctgttcgcacggataacggttatcgcagctacacggccaaacatattgaagagctcacgttgctgcgccaggcgcggcaagtgggttttacactggatgagtgtcgtgaattgctggcattatttcataacccagcacggcacagcgcggatgtgaaagcggcaacattgctaaaagtagcggaaatcgagcaacatattaatgatttgaatcagatgcgtatgcgtttgttagcgttggcagaagagtgcccaggggatgagggcgcagattgcccaattattaatagcctggcgggatgttgccactcaagcagttcgctaccattaaaataa
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
Chris J. Myers
James Alastair McLaughlin
2017-03-06T15:00:00.000Z