BBa_M36543 1 BBa_M36543 Calcium Induced Promoter 2012-12-07T12:00:00Z 2015-05-08T01:14:05Z The part comes from the 2000 base pairs upstream of the human prolactin (PRL) gene. This part is the promoter of the human prolactin (PRL) gene, which has been shown to be activated by increased levels of Ca2+ in cells. As there is little conclusive information about mammalian promoters other than they can be found in genetic control regions (usually upstream of the target gene), the genetic sequence was taken from the 2000 bases upstream of PRL in the human genome. Since this selection included a TATAA box, indicative of promoters that initiate at specific sites, it was possible to infer the presence of the PRL promoter. false false _848_ 0 15051 9 Not in stock false There were no changes to the original sequence, even for optimization purposes or to minimize repeats, due to the lack of information about mammalian promoters. This meant that any codon optimization could affect an area critical to the function of the promoter. false Anna McGregor, Maya Anjur-Dietrich, and Kay Hung annotation2213698 1 TATAA Box (Characteristic of a Promoter) range2213698 1 302 306 annotation2213699 1 PRL Promoter Region range2213699 1 1 1998 BBa_M36543_sequence 1 catcacctccaatggtaataatagcatagcttctctcaagtggtcgacagataaccttttatctctttttttaatttacaagaattctttgagtttcattccactaatgatgtagaagtgacaagtgaaaaagttaaatgaaaattttatgacacatgcaagactcatattagtaaaagaattcttagagactgaaatggcagataaatcaaagaccaatttgaagacgaaaaaaattaatagcttctcatcccttatctgcataactcattaagaaatagtctaacaaacgtattgtttttataacatgattcagaatcacacgcaaattatctttgacagtggccatgttttcttaaagatgctgaattcttcagaacattccatttatctctcctctctctttggaaacccaattaccttggcatttttccttgaagtaataatgtgtttcacaaggtgtcttcgaggtcacatctttatttcctcaccaagacttaccatcagctgcataagaagctcagtgggcacataaaaaggcatacagaagtgggcagacagaaggcaagaagaaatattaccagtatggcaggagaaagaattggagttccagtgccagttctttcagtaattaaatatgtttacatcattttctttatttctgtaatgtgatatttggttagaattagtccatgtttcctctacctctgcaatactatgatttagacaaattagagattgtccagaagttgagcctcaggatggttaatcttaatggatgaacagattgaaattgaattgaacataggcaggagaaaatggaggagaagctattgtaatatgcaggtcaagataacctggagaaaggaggaaagataattttatggagttagagagacagaataattgccacctgccaactggttgagtgtgatgcaagggaaacaaaagaaaaggaaataaactcaactctgagatgttaagtgttgactgagaagctgtttgagagaaaagatgaatcattaaggattttctttaataaatcagcatatcttacttgtagacatatagattgaaatgtctagcaggtaattagtagctcagaagtcaacttagggagagataaacagagctgggatcatcttcatggatgtgacaaataaagtcatgacattgaataagacagccaaagggggcagtacaaggttgaatgccaacaaaaattaacatagataagaactcaaggaattatttagattcagccattaaacaatcatggtaacgagtaagagaaaacaaaacaaactaaactatttatatattatttttgccatatgttctattgtagatgttctaggtgcttgaaatacacacacccatatcctactcttgagtcttggttaatttcccctcacatttgtttaatgcatgcttaatatttttgatcctattattgattgcaaaaagactatagacagtctcatctccattattgactgcatatcaatacaatatcacaaagtactgtactatgctttaacatttttgcctagtaacaaatttattactccagcaatttaatttgcttgctgtgattttttgtacttcaacgtttttagacactccattttaatctaggtttttcaaaagcagcactactgacatttggatggcataatattatgttctgagggctgctctgtgtgttgtaagatgtttagcaacatgtctggtctctgctcaccagatgccagcagcacccccacttccagttatgacagtcataaacatcttcacacattgccaaatgtctcctgggaggcagaatcacctcctaactgcttgccctttgaaaaccactcatttagattgatggggttcagaacacactaccacaaaatatggcatcttggcatttcagaaaacagcaaaaacaggaagttcactctgtaagcttctcccacccttctcccctgaagcaggccataaaagaatcct igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z