BBa_M50000
1
eCPX-nSA-c
Streptavidin binding outer membrane protein
2016-10-23T11:00:00Z
2016-12-09T07:58:12Z
Derived from E. coli outer membrane protein OmpX. eCPX is an engineered version of OmpX developed by Rice and Daugherty (Protein Eng. Des. Sel., 2008, pg 435-442)
Cell surface display protein with N-terminal and C-terminal streptavidin binding domain. eCPX-nSA-cNano will be used to make E. coli bind to streptavidin coated magnetic beads, enabling bacterial capture.
false
false
_848_
34382
34382
9
false
eCPX was developed as a biterminal display scaffold, and thus both N and C termini are available for fusion with other domains. An N terminal fusion with a streptavidin binding domain had already been created by Rice and Daugherty for their paper on eCPX; we wished to increase the affinity by fusing another (stronger binding) streptavidin binding domain to the C terminus
false
Nicolas Quach
annotation2530174
1
Ser-Gly linker
range2530174
1
617
634
annotation2530172
1
NanoTag
range2530172
1
635
679
annotation2530173
1
SA-binding domain
range2530173
1
86
130
BBa_M50003
1
BBa_M50003
StickyGreen
2016-10-24T11:00:00Z
2016-10-25T05:42:32Z
N/A
Bicistronic construct allowing linked expression of eCPX-nSA-cNano, a cell surface display protein containing two streptavidin binding domains, and mNeonGreen, a bright green fluorescent protein. A spacer separates the two genes. Both genes are preceded by a strong RBS.
false
false
_848_
34382
34382
9
false
It is unclear whether a spacer is necessary to separate the two genes. We included the spacer sequence to ensure even expression of the two genes by preventing possible ribosome collision events.
false
Nicolas Quach
component2529055
1
BBa_M50000
component2529054
1
BBa_B0034
component2529056
1
BBa_M50001
component2529059
1
BBa_M50002
component2529058
1
BBa_B0034
annotation2529056
1
BBa_M50001
range2529056
1
690
719
annotation2529059
1
BBa_M50002
range2529059
1
746
1456
annotation2529058
1
BBa_B0034
range2529058
1
728
739
annotation2529055
1
BBa_M50000
range2529055
1
19
681
annotation2529054
1
BBa_B0034
range2529054
1
1
12
BBa_B0034
1
BBa_B0034
RBS (Elowitz 1999) -- defines RBS efficiency
2003-01-31T12:00:00Z
2015-08-31T04:07:20Z
Released HQ 2013
RBS based on Elowitz repressilator.
false
true
_1_
0
24
7
In stock
false
Varies from -6 to +1 region from original sequence to accomodate BioBricks suffix. <p>No secondary structures are formed in the given RBS region. Users should check for secondary structures induced in the RBS by upstream and downstream elements in the +50 to -50 region, as such structures will greatly affect the strength of the RBS.
Contact info for this part: <a href="mailto:(bchow@media.mit.edu)">Brian Chow</a>
true
Vinay S Mahajan, Voichita D. Marinescu, Brian Chow, Alexander D Wissner-Gross and Peter Carr IAP, 2003.
annotation23325
1
conserved
range23325
1
5
8
BBa_M50002
1
BBa_M50002
mNeonGreen
2016-10-23T11:00:00Z
2016-10-25T05:38:05Z
Branchiostoma lanceolatum
Full sequence for the ultra bright green fluorescent protein mNeonGreen. It is currently the brightest GFP. Codon optimized for E. coli K12.
false
false
_848_
34382
34382
9
false
None.
false
Nicolas Quach
annotation2530175
1
mNeonGreen
range2530175
1
1
711
BBa_M50001
1
BBa_M50001
DNA spacer sequence
2016-10-23T11:00:00Z
2016-12-09T08:45:49Z
Derived from the lambda phage genome. The 30 bp correspond to a portion of the untranslated region of the late transcript, between genes Q and S.
A 30bp DNA spacer sequence. Used to prevent ribosome collision in bicistronic constructs.
false
false
_848_
34382
34382
9
false
It is unclear whether spacer sequences are truly necessary to separate two genes, nor is it clear how long such a sequence would need to be.
false
Nicolas Quach
annotation2532379
1
spacer
range2532379
1
1
15
BBa_M50000_sequence
1
atgaagaagattgcatgtctttcagcccttgctgccgtgttggccttcactgccggaacgagcgttgcaggccagtcaggtcaagcagagtgccatccccagggccccccttgcatcgaaggccgtaagggtggacaaagcggccagtcgggagattataacaaaaaccaatactacggtattacggctggaccagcataccgcatcaacgattgggcttctatttatggggtggttggagttggctatggtaaattccaaacgacagagtaccccacttataagcacgatacctctgattatgggttctcctacggcgcaggacttcagtttaatccgatggagaacgtagcattagatttctcgtatgagcagagtcgtatccgctcagtggacgttggtacttggatcttgtcagtggggtatcgcttcggctcgaagtctcgccgcgctacgtccactgtgacaggtggatatgcccagagcgacgcacaagggcagatgaacaaaatgggtggctttaaccttaagtaccgttatgaggaagataattcaccccttggggttatcggctcctttacctacacagaaaagtcccgcaccgcgagtgggggaagtggtggaggttcgggagatgttgaggcatggctgggagctcgcgtcccgcttgtagaaacctaa
BBa_B0034_sequence
1
aaagaggagaaa
BBa_M50003_sequence
1
aaagaggagaaatactagatgaagaagattgcatgtctttcagcccttgctgccgtgttggccttcactgccggaacgagcgttgcaggccagtcaggtcaagcagagtgccatccccagggccccccttgcatcgaaggccgtaagggtggacaaagcggccagtcgggagattataacaaaaaccaatactacggtattacggctggaccagcataccgcatcaacgattgggcttctatttatggggtggttggagttggctatggtaaattccaaacgacagagtaccccacttataagcacgatacctctgattatgggttctcctacggcgcaggacttcagtttaatccgatggagaacgtagcattagatttctcgtatgagcagagtcgtatccgctcagtggacgttggtacttggatcttgtcagtggggtatcgcttcggctcgaagtctcgccgcgctacgtccactgtgacaggtggatatgcccagagcgacgcacaagggcagatgaacaaaatgggtggctttaaccttaagtaccgttatgaggaagataattcaccccttggggttatcggctcctttacctacacagaaaagtcccgcaccgcgagtgggggagatgttgaggcatggctgggagctcgcgtcccgcttgtagaaacctaatactagagcatatcggtcacgaacaaatctgattactatactagagaaagaggagaaatactagatggtgtcaaaaggcgaggaggataatatggcctcgcttccagcgacgcacgagttgcatattttcggatctattaacggtgttgattttgacatggtaggtcagggcacggggaaccccaatgatggctatgaggaattaaatctgaaatcgacaaaaggggatttgcagttctccccatggatcttagttccacacatcggatatggcttccaccaatacttgccgtaccctgatgggatgtctccttttcaggcggccatggtggacggatctggctaccaagtacaccgtacaatgcaattcgaagatggtgcctcgttgaccgtaaactatcgttacacttacgaaggttcacacatcaagggagaagcccaggtaaagggcactggtttcccagccgatggccctgtcatgactaattctttgaccgcagcagattggtgccgttccaagaaaacctatccgaacgacaagacgatcatttcaacgttcaaatggagctacacgaccggaaacggaaagcgttatcgctctactgctcgtactacctacacatttgccaaaccgatggccgctaattatttaaaaaaccagcctatgtatgttttccgtaaaaccgagttgaaacactccaaaacagaacttaattttaaggagtggcagaaggcttttactgacgtaatgggtatggatgagttatataagtaa
BBa_M50001_sequence
1
catatcggtcacgaa
BBa_M50002_sequence
1
atggtgtcaaaaggcgaggaggataatatggcctcgcttccagcgacgcacgagttgcatattttcggatctattaacggtgttgattttgacatggtaggtcagggcacggggaaccccaatgatggctatgaggaattaaatctgaaatcgacaaaaggggatttgcagttctccccatggatcttagttccacacatcggatatggcttccaccaatacttgccgtaccctgatgggatgtctccttttcaggcggccatggtggacggatctggctaccaagtacaccgtacaatgcaattcgaagatggtgcctcgttgaccgtaaactatcgttacacttacgaaggttcacacatcaagggagaagcccaggtaaagggcactggtttcccagccgatggccctgtcatgactaattctttgaccgcagcagattggtgccgttccaagaaaacctatccgaacgacaagacgatcatttcaacgttcaaatggagctacacgaccggaaacggaaagcgttatcgctctactgctcgtactacctacacatttgccaaaccgatggccgctaattatttaaaaaaccagcctatgtatgttttccgtaaaaccgagttgaaacactccaaaacagaacttaattttaaggagtggcagaaggcttttactgacgtaatgggtatggatgagttatataagtaa
igem2sbol
1
iGEM to SBOL conversion
Conversion of the iGEM parts registry to SBOL2.1
James Alastair McLaughlin
Chris J. Myers
2017-03-06T15:00:00.000Z