Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Andre' Green II
Date created: 2006-05-15 11:00:00
Date modified: 2015-08-31 04:07:30
Calcium-sensing receptor protein
| Types | DnaRegion |
| Roles | Coding CDS |
| Sequences | BBa_I10501_sequence (Version 1) |
Description
CaR has been shown to be crucial in a myriad of metabolic pathways, reflecting the importance of Ca2+ in many different processes. Most recently, CaR has been shown to be expressed on the surface of human oocytes and aortic endothelial cells.The following summary can be found at NCBI: "The calcium-sensing receptor (CASR) functions as a sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, whereas mutations that activate CASR are the cause of autosomal dominant hypocalcemia."
| Sequence Annotation | Location | Component / Role(s) |
| Receptor Family Ligand Binding Region Receptor Family Ligand Binding Region Transmembrane Receptor | 1227,1485 204,1029 1845,2601 | feature/binding non_covalent_binding_site non_covalent_binding_site feature/binding sequence_feature feature/misc |