BBa_I10888

BBa_I10888 Version 1

Component

Source: http://parts.igem.org/Part:BBa_I10888

Generated By: https://synbiohub.org/public/igem/igem2sbol/1

Created by: Tracy Chang

Date created: 2006-04-24 11:00:00

Date modified: 2015-08-31 04:07:30

Human Tyrosine Kinase Receptor(TrkA)

Details

• Types: DnaRegion
• Roles: Coding; CDS
• Sequences: BBa_I10888_sequence (Version 1)

Description

This gene encodes a member of the neurotrophic tyrosine
kinase receptor (NTKR) family. This kinase is a membrane-bound
receptor that, upon neurotrophin binding, phosphorylates itself and
members of the MAPK pathway. The presence of this kinase leads to
cell differentiation and may play a role in specifying sensory
neuron subtypes. Mutations in this gene have been associated with
congenital insensitivity to pain, anhidrosis, self-mutilating
behavior, mental retardation and cancer. Alternate transcriptional
splice variants of this gene have been found, but only three have
been characterized to date.

Other Properties

• igem#experience: None
• igem#sampleStatus: Not in stock
• igem#status: Unavailable
• synbiohub#ownedBy: user/james
• synbiohub#ownedBy: user/myers
• synbiohub#topLevel: BBa_I10888/1

Member of these Collections

• iGEM Parts Registry