BBa_J120000

BBa_J120000 Version 1

Component

Source: http://parts.igem.org/Part:BBa_J120000

Generated By: https://synbiohub.org/public/igem/igem2sbol/1

Created by: Corinthia Black, Sheree Harper, Srikanth Sistla, Anna Wieman

Date created: 2012-04-09 11:00:00

Date modified: 2015-08-31 04:08:29

Coding sequence for PARP1 (poly [ADP-ribose] polymerase 1) H. sapiens

Details

• Types: DnaRegion
• Roles: CDS; Coding
• Sequences: BBa_J120000_sequence (Version 1)

Description

Coding sequence for PARP1 (poly[ADP-ribose] polymerase 1) which is instrumental in detecting damaged DNA, directly binding to it and catalyzing its repair. During apoptosis, PARP1 is typically cleaved, inhibiting its function. The sequence was originally obtained from NCBI (accession # NM_001618.3). This sequence was modified to remove internal restriction sites by changing the third base of the codons at these sites.

Notes

Two internal restriction enzyme recognition sites were found in the sequence. To prevent cleavage by restriction enzymes, the third base of the codons at these sites were changed.

Source

NCBI (accession # NM_001618.3)

Other Properties

• igem#experience: None
• igem#sampleStatus: Not in stock
• igem#status: Unavailable
• rdf-schema#seeAlso: P09874
• synbiohub#ownedBy: user/james
• synbiohub#ownedBy: user/myers
• synbiohub#topLevel: BBa_J120000/1

Member of these Collections

• iGEM Parts Registry