Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Sanjana Gurrala, Xiaoyang Feng, Stephen Cain, Orijit Kar, Sahil Sharma
Date created: 2012-04-02 11:00:00
Date modified: 2015-08-31 04:08:29
TACE(Tumor necrosis factor-α
-converting enzyme) aka ADAM17 endopepsidase (H. sapiens)
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_J120025_sequence (Version 1) |
Description
ADAM17, also known as tumor necrosis factor ∂ converting enzyme (TACE) is activated by several tyrosine kinase receptors, and is known to be over expressed in cancerous cells. It is an integral transmembrane metalloprotease that produces TNF-∂ and participates in ectodomain shedding of other transmembrane proteins. This part has to be linked with promoter in order to be expressed in yeast.Notes
atgcgccagagcctgctgtttctgaccagcgtggtgccgtttgtgctggcgccgcgcccgccggatgatccgggctttggcccgcatcagcgcctggaaaaactggatagcctgctgagc
gattatgatattctgagcctgagcaacattcagcagcatagcgtgcgcaaacgcgatctg
cagaccagcacccatgtggaaaccctgctgacctttagcgcgctgaaacgccattttaaa
ctgtatctgaccagcagcaccgaacgctttagccagaactttaaagtggtggtggtggat
ggcaaaaacgaaagcgaatataccgtgaaatggcaggatttttttaccggccatgtggtg
ggcgaaccggatagccgcgtgctggcgcatattcgcgatgatgatgtgattattcgcatt
aacaccgatggcgcggaatataacattgaaccgctgtggcgctttgtgaacgataccaaa
gataaacgcatgctggtgtataaaagcgaagatattaaaaacgtgagccgcctgcagagc
ccgaaagtgtgcggctatctgaaagtggataacgaagaactgctgccgaaaggcctggtg
gatcgcgaaccgccggaagaactggtgcatcgcgtgaaacgccgcgcggatccggatccg
atgaaaaacacctgcaaactgctggtggtggcggatcatcgcttttatcgctatatgggc
cgcggcgaagaaagcaccaccaccaactatctgattgaactgattgatcgcgtggatgat
atttatcgcaacaccagctgggataacgcgggctttaaaggctatggcattcagattgaa
cagattcgcattctgaaaagcccgcaggaagtgaaaccgggcgaaaaacattataacatg
gcgaaaagctatccgaacgaagaaaaagatgcgtgggatgtgaaaatgctgctggaacag
tttagctttgatattgcggaagaagcgagcaaagtgtgcctggcgcatctgtttacctat
caggattttgatatgggcaccctgggcctggcgtatgtgggcagcccgcgcgcgaacagc
catggcggcgtgtgcccgaaagcgtattatagcccggtgggcaaaaaaaacatttatctg
aacagcggcctgaccagcaccaaaaactatggcaaaaccattctgaccaaagaagcggat
ctggtgaccacccatgaactgggccataactttggcgcggaacatgatccggatggcctg
gcggaatgcgcgccgaacgaagatcagggcggcaaatatgtgatgtatccgattgcggtg
agcggcgatcatgaaaacaacaaaatgtttagcaactgcagcaaacagagcatttataaa
accattgaaagcaaagcgcaggaatgctttcaggaacgcagcaacaaagtgtgcggcaac
agccgcgtggatgaaggcgaagaatgcgatccgggcattatgtatctgaacaacgatacc
tgctgcaacagcgattgcaccctgaaagaaggcgtgcagtgcagcgatcgcaacagcccg
tgctgcaaaaactgccagtttgaaaccgcgcagaaaaaatgccaggaagcgattaacgcg
acctgcaaaggcgtgagctattgcaccggcaacagcagcgaatgcccgccgccgggcaac
gcggaagatgataccgtgtgcctggatctgggcaaatgcaaagatggcaaatgcattccg
ttttgcgaacgcgaacagcagctggaaagctgcgcgtgcaacgaaaccgataacagctgc
aaagtgtgctgccgcgatctgagcggccgctgcgtgccgtatgtggatgcggaacagaaa
aacctgtttctgcgcaaaggcaaaccgtgcaccgtgggcttttgcgatatgaacggcaaa
tgcgaaaaacgcgtgcaggatgtgattgaacgcttttgggattttattgatcagctgagc
attaacacctttggcaaatttctggcggataacattgtgggcagcgtgctggtgtttagc
ctgattttttggattccgtttagcattctggtgcattgcgtggataaaaaactggataaa
cagtatgaaagcctgagcctgtttcatccgagcaacgtggaaatgctgagcagcatggat
agcgcgagcgtgcgcattattaaaccgtttccggcgccgcagaccccgggccgcctgcag
ccggcgccggtgattccgagcgcgccggcggcgccgaaactggatcatcagcgcatggat
accattcaggaagatccgagcaccgatagccatatggatgaagatggctttgaaaaagat
ccgtttccgaacagcagcaccgcggcgaaaagctttgaagatctgaccgatcatccggtg
acccgcagcgaaaaagcggcgagctttaaactgcagcgccagaaccgcgtggatagcaaa
gaaaccgaatgc