BBa_K1061002

BBa_K1061002 Version 1

Component

Source:
http://parts.igem.org/Part:BBa_K1061002
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: mengyi sun
Date created: 2013-09-10 11:00:00
Date modified: 2015-05-08 01:08:58

RIP 1



Types
DnaRegion

Roles
CDS

Coding

Sequences BBa_K1061002_sequence (Version 1)

Description

Receptor interacting protein 1, a serine/threonine kinase that play an important role in cell apoptosis and necrosis. Overexpression of RIP 1 in cancer cells may induce cell death.

Notes

It has been reported that besides apoptosis, RIP 1 can also induce necrosis in cells , we also observe this effect in Hep G2 cell lines, and now we are try to find more suitable gene that can only induce apoptosis and avoid the inflammation effect. To use the RIP 1 to treat cancer, tightly control of expression may be necessarily.

Source

We cloning this part from human genomocs via RT-PCR

igem#experience
Works
 
igem#sampleStatus
It's complicated
igem#status
Planning
 
rdf-schema#seeAlso
Q13546
 
synbiohub#ownedBy
user/myers
 
synbiohub#ownedBy
user/james
 
synbiohub#topLevel
BBa_K1061002/1