Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Shinjini Saha
Date created: 2014-10-16 11:00:00
Date modified: 2015-05-08 01:10:14
pENTR_LilrB2
| Types | DnaRegion |
| Roles | Plasmid plasmid |
| Sequences | BBa_K1391011_sequence (Version 1) |
Description
LilrB2 (leukocyte immunoglobin-like receptor B2) is a transmembrane protein found in human neurons shown to bind to beta-amyloid. The interactions is mediated by the first two extracellular immunoglobulin (Ig) domains. Upon binding to beta-amyloid (extracellular), LilrB2 induces enhanced cofilin signaling (intracellular).Taeho Kim, George S. Vidal, Maya Djurisic, et al. "Human LilrB2 is a beta-amyloid recptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's Model". Science. 20 Sep 2013.