| Types || |
| Roles |
| Sequences || BBa_K1420004_sequence (Version 1)|
DescriptionmerR, located upstream of the rest of the mer genes, serves to regulate the operon. The MerR protein contains a C-terminal effector binding region that recognizes ionic mercury. Upon binding it, the protein???s N-terminal helix-turn-helix DNA binding domain can bind the merR promoter region to induce transcription of the operon. The effector binding region of the protein can vary allowing for great diversity in merR-like promoters that can respond to a variety of heavy metals as well as antibiotics and oxidative stress.
SourceSource organism: Serratia marcescens. Amplified from plasmid pDU1358, kindly donated by Anne O. Summers.