Types | DnaRegion
|
Roles | promoter
Regulatory
|
Description
EGP-2 is located upstream of EPCAM.
this promoter is shortened to sustain promoter function.
this is cloned from human cell.
Notes
EPCAM is expressed in CTC.
Therefore, EGP-2 is considered to be a good candidate for a marker.
Source
1. McLaughlin, P. M., Trzpis, M., Kroesen, B. J., Helfrich, W., Terpstra, P., Dokter, W. H., ... & Harmsen, M. C. (2004). Use of the EGP-2/Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines. Cancer gene therapy, 11(9), 603-612.
2.Danda, R., Krishnan, G., Ganapathy, K., Krishnan, U. M., Vikas, K., Elchuri, S., ... & Krishnakumar, S. (2013). Targeted Expression of Suicide Gene by Tissue-Specific Promoter and MicroRNA Regulation for Cancer Gene Therapy. PloS one, 8(12), e83398.