Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Danielle Peters
Date created: 2014-09-18 11:00:00
Date modified: 2015-05-08 01:10:44
ER Intein
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_K1491024_sequence (Version 1) |
Description
The intein contains the human E2 estrogen ligand binding domain. When estrogen binds to the receptor, the intein splices out of the protein and joins the N and C terms of the protein, thereby activating it. This allows for an estrogen sensitive protein.Notes
Estrogen sensitive inteinSource
Chong, Shaorong, Kay S. Williams, Chad Wotkowicz, and Ming-Qun Xu. "Modulation of Protein Splicing of the Saccharomyces Cerevisiae Vacuolar Membrane ATPase Intein." Journal of Biological Chemistry 273.17 (1998): 10567-0577.| Sequence Annotation | Location | Component / Role(s) |
| N term Intein Estrogen Receptor C term Intein | 1,615 616,1373 1374,1575 | feature/misc sequence_feature feature/binding non_covalent_binding_site sequence_feature feature/misc |