Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Willy Hsu
Date created: 2014-10-06 11:00:00
Date modified: 2015-05-08 01:10:47
Skin whitening substance generator (PhoA signal sequence + PKEK)
| Types | DnaRegion |
| Roles | Coding CDS |
| Sequences | BBa_K1507022_sequence (Version 1) |
Description
In E.coli Type II secretion system, the signal sequence(In here is PhoA) can bring the target protein to the inner-membrane， and transfer the target protein to the outer space. There are many candidates sequence for guiding or protein product, so we choose three of them(All of them have been studied for a long period of time by other laboratory), to make sure the signal sequence is suit for the transportation of our target proteins.PKEK, comprise of Pro-Lys-Glu-Lys, is a tetraoligopeptide that has the strong effect of whitening our skin. By down-regulating the mRNA expression of interleukin (IL)-6, IL-8 and TNF-α and tyrosinase, it can prevent the formation of eumelanin.
Another advantage why we choose PKEK is it can easily penetrate the skin barrier and have its maximum
Notes
No dataSource
E.coliArtificial synthesis