Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: MIN YI YOU
Date created: 2015-08-27 11:00:00
Date modified: 2015-08-28 12:54:53
peptide yy (PYY)
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_K1841005_sequence (Version 1) |
Description
Peptide YY is a short peptide that can restrain our appetite. Because the peptide???s head and tail are both amino acid, tyrosine (Y), it is named peptide YY (PYY). PYY has two forms: PYY 1-36 is the unmodified form, and PYY 3-36 is the kind of PYY cut off two amino acids in N-terminal side by dipeptidyl peptidase-IV. Each contains 60% and 40% of all PYY.In the situation of PYY binding to the receptors, PYY 1-36???s affinity to Y1, Y2, Y4,and Y5 are all high. However, because PYY 3-36 is cut off two amino acids in N-terminal side causing conformational change, its affinity to Y2 is higher than others. Since both two types of PYY don???t require disulfide bond to stable its structure, it can spontaneously become a stable and activated form in the solution. PYY is classified as gastrointestinal(GI) hormone. After intestine absorbs micromolecule nutrients, ileum and colon epithelial cells will secret PYY to blood. As PYY contact hypothalamus by blood circulation.