Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Choi Yan Ru
Date created: 2016-10-08 11:00:00
Date modified: 2016-10-09 02:50:37
HasR Membrane receptor coding sequence
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_K1897002_sequence (Version 1) |
Description
HasR is the membrane-bound receptor in the Has system, a heme acquisition system originally from the Serratia marcescens. The HasR protein is involved in binding with a heme-loaded HasA hemophore to trigger downstream HasS and HasI. It has been shown that the N terminal of HasR is especially crucial for signal transduction. With the heme-loaded hasA bound to hasR, it induces a conformational change in HasR that causes the activation of HasS, an anti-sigma factor. HasS then releases HasI (sigma factor) that was initially bound to it and HasI ultimately is able to trigger expression of genes under control of pHas (part number).Notes
NILSource
The HasR gene is originally found in the Serratia marcescens. We obtained the gene sequence from the National Center for Biotechnology Information (NCBI) database (http://www.ncbi.nlm.nih.gov/nuccore/X81195.2) and synthesised the gene.| Sequence Annotation | Location | Component / Role(s) |
| Start codon HasR Stop codon | 1,3 1,2700 2698,2700 | feature/start start_codon feature/cds CDS feature/stop stop_codon |