| Types | DnaRegion
|
| Roles | CDS
Coding
|
| Sequences | BBa_K2107002_sequence (Version 1)
|
Description
This Biobrick codes for a modified version of Platelet Derived Growth Factor-B. There are many Isoforms for PDGF-B, many of which have identical binding sites but have differing flanking regions. Throughout extensive literature research and analysis of protein folding models we determined that some of these flanking regions may be unnecessary.
Notes
This part contains the same active site as PDGF-B isoform 1, but has been shortened to remove unnecessary flanking regions and decrease cost on the cell chassis to increase yield a protein folding efficiency.
Source
TAGAGAAAGAGGGGACAAACCAGTATGATTGCGGAATGCAAAACCCGCACCGAAGTGTTTGAAATTAGCCGCCGCCTGATTGATCGCACCAACGCGAACTTTCTGGTGTGGCCGCCGTGCGTGGAAGTGCAGCGTTGCAGCGGCTGCTGCAACAACCGCAACGTGCAGTGCCGCCCGACCCAGGTGCAACTGCGCCCGGTGCAGGTGCGCAAAATTGAAATTGTGCGCAAAAAACCGATTTTTAAAAAAGCGACCGTGACCCTGGAAGATCATCTGGCGTGCAAATGCGAAACCGTGCATCATCACCATCACCACTAATGA
