| Types | DnaRegion
|
| Roles | CDS
Coding
|
| Sequences | BBa_K364306_sequence (Version 1)
|
Description
The constitutive androstane receptor (CAR) also known as nuclear receptor subfamily 1, group I, member 3 is a protein that in humans is encoded by the NR1I3 gene.[1] CAR is a member of the nuclear receptor superfamily and along with PXR functions as a sensor of endobiotic and xenobiotic substances and in response upregulates the expression of proteins responsible for the metabolism and excretion of these substances.[2] Hence CAR (and PXR) are important in the detoxification of foreign substances such as drugs.
Notes
This part will be fused with DBD and Backbone(PSB1C3) via 3-way assembly in accord with RFC25.
Source
nuclear hormone receptor superfamily
