Types | DnaRegion
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Roles | CDS
Coding
|
Sequences | BBa_K364310_sequence (Version 1)
|
Description
The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction.
The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids.
Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes,WHICH Ultimately causes physiological changes that result in ecdysis (moulting).
Notes
The reconstruction of the DBD to the hinge region, LBD and Backbone will be done with RFC 25
Source
Human EcR (of the nuclear hormone receptor superfamily)