RUNX2

BBa_K415501 Version 1

Component

Source: http://parts.igem.org/Part:BBa_K415501

Generated By: https://synbiohub.org/public/igem/igem2sbol/1

Created by: Laura Deming, Joy Jiao, Adrian Slusarczyk

Date created: 2010-10-23 11:00:00

Date modified: 2015-05-08 01:12:27

RUNX2 L1L2 MammoBlock Entry Vector

Details

• Types: DnaRegion
• Roles: Coding; CDS
• Sequences: BBa_K415501_sequence (Version 1)

Description

RUNX2, or runt-related transcription factor, is a master osteoblast differentiation transcription factor; it is a downstream target of BMP-2 and switches on transcription of multiple effectors of osteoblast development. NCBI page with sequence, gene information etc. http://www.ncbi.nlm.nih.gov/gene/860

Isoforms: There are three isoforms of RUNX2 in humans, this part contains isoform Type-II, alpha, which is the longest and includes the 3' exon.

Notes

We wanted to use the longest RUNX2 isoform; this isoform has been shown to induce bone differentiation when transfected into human cells.

Source

Obtained as an L1L2 Entry vector from Open Biosystems.

Sequence Annotations

Sequence Annotation	Location	Component / Role(s)
RUNX2 cDNA	21,1605	CDS, feature/protein

Other Properties

• igem#experience: None
• igem#sampleStatus: It's complicated
• igem#status: Planning
• synbiohub#ownedBy: user/james
• synbiohub#ownedBy: user/myers
• synbiohub#topLevel: BBa_K415501/1

Member of these Collections

• iGEM Parts Registry