Types | DnaRegion
|
Roles | Composite
engineered_region
|
Description
Microcin C51 is a bacteriocin protein produced by the Escherichia coli pMccC51 plasmid. They make holes in bacterial membranes, being lethal.
In our project, we used Microcin C51 to kill pathogen cells (in our case they were E.coli DH5alpha strain) by membrane lysis, disinfecting the contaminated water.
Notes
Please see K, Severinov et al. PROKARYOTIC ANTIMICROBIAL PEPTIDES, 2011, Part 5, 289-308, Class I Microcins: Their Structures, Activities,
and Mechanisms of Resistance. for info on this point.
Source
the sequence of the Escherichia coli pMccC51 plasmid have been deposited under the accession numbers AJ487788.2 in the EMBL/Genbank database.
This part was central in our 2011 iGEM project: http://2011.igem.org/Team:Valencia