Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Ernesto G??mez
Date created: 2011-09-27 11:00:00
Date modified: 2015-05-08 01:13:01
Rhamnose production BioBrick
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_K653004_sequence (Version 1) |
Description
In addition to the direct use of rhamnolipids, they are also used as commercial sources of rhamnose sugar. It is not ideal to have plants as a source of an industrial compound, since their availability may be limited. Many companies prefer to obtain industrial natural products from genetically engineered sources.There are myriad other uses for this sugar. For instance, there is an overexpression system in which the production of the desired gene is triggered by adding sterilized rhamnose to the genetically engineered bacteria. A rhamnose test is available for intestinal permeability in humans. Many prescription drugs, such as non-steriodal anti-inflammatory drugs (NSAIDs), can cause intestinal damage that manifests as leakage through the intestines. Having patients drink a solution of lactulose and L-rhamnose is one way of testing for this condition.
With just any carbon source now our modify bacteria along with this rhamnose BioBrick can produce rhamnolipids and many other applications.
Notes
He have to perform silent mutations because the sequence shows three illegal restriction site and goe against the Assembly Standard protocol 10. In process!Source
The rml gene cluster for rhamnose biosynthesis involved: rmlB, rmlD, rmlA, rmlC group of genes.http://www.ncbi.nlm.nih.gov/gene?term=rmlB%20PAO1