| Types | DnaRegion
|
| Roles | promoter
Regulatory
|
| Sequences | BBa_K763005_sequence (Version 1)
|
Description
There are two transcriptional factors which regulates the ADH2 promoter: ADR1 a carbon source-responsibe zinc-finger2 and CAT83. In the absence of glucose both cis-acting sites in the promoter are bound cooperatively by the transcriptional activators. ADR1 binds to the UAS1 site while CAT8 binds to the UAS2/CSRE site and regulates positively the transcription of YAP1 protein by the activation of the ADH2 promoter. The presence of glucose downregulates the levels of the transcription factors (ADR1 and CAT8) which results in the depletion of the production of YAP1 protein by the repression of the ADH2 promoter.
Notes
No design considerations needed.
Source
The sequences of the promoter and the gene which encodes the YAP1 protein comes from yeast Sacharomyces cerevisiae genome.
