Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Melissa Ko
Date created: 2009-05-11 11:00:00
Date modified: 2015-05-08 01:13:55
human MRC2
| Types | DnaRegion |
| Roles | polypeptide_domain Protein_Domain |
| Sequences | BBa_M12064_sequence (Version 1) |
Description
also known as uPARAP/Endo 180, transmembrane enzyme that is used to bind collagen and initiate receptor-mediated endocytosis to bring collagen into the cell and cause degradation of the collagen, important for the turnover of the extracellular matrixNotes
pulled from human genome, to use in bacterial systems the introns should be removed from sequence, exons are as follows: 1..520, 37148..37549, 38694..38867, 39055..39219, 39357..39470, 39990..40133, 44249..44437, 44598..44752, 46663..46770, 48390..48505, 48983..49131, 49869..50086, 51104..51246, 52400..52502, 52770..52908, 53018..53053, 53400..53560, 53662..53729, 54437..54537, 54835..54977, 60889..61003, 61101..61264, 61452..61560, 62122..62360, 62494..62662, 62756..62905, 63242..63361, 63549..63728, 64712..64738, 64831..66192Source
Homo sapiens genomic sequence documented in "Finishing the euchromatic sequence of the human genome" published in Nature on 21 October 2004; function documented in "Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells andmacrophages and functions as a lectin receptor" by Humma Sheikh, Helen Yarwood, Alan Ashworth, and Clare M. Isacke; mouse homolog sequence described in "Characterization of a Novel Member of the Macrophage Mannose Receptor Type C Lectin Family" by Kai Wu, Jean Yuan, and Laurence A. Lasky