| Types | DnaRegion
|
| Roles | sequence_feature
Other
|
| Sequences | BBa_M41008_sequence (Version 1)
|
Description
The Axonal Myelination Initiator is an innovative device that promotes the production of myelin. The part receives inputs from two separate systems: the axon recognizing device, which produces the chaperone protein coded by the gene invF; and the axon-cell adhesion device, which produces the transcription factor coded by the gene sic A. The chaperone protein activates the otherwise inactive transcription factor and the complex promotes the transcription of myelin producing genes, successfully integrating two inputs to provide an extra level of control to the myelination system. The activated transcription complex binds to the listed sequence.
Notes
The promoter was designed in such a way as to initiate transcription of a gene cluster only when inputs are received from both the axon recognizing and adhesion devices.
Source
This part is based off of the genomic sequence of Salmonella typhimurium which has a similar promoter.
