Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Changlong Zhao
Date created: 2013-09-11 11:00:00
Date modified: 2015-05-08 01:09:02
Protective Antigen Domain 4
| Types | DnaRegion |
| Roles | Coding CDS |
| Sequences | BBa_K1074004_sequence (Version 1) |
Description
Protective antigen (PA) is the central component of the three-part protein toxin secreted by Bacillus anthracis, the organism responsible for anthrax. Homologues of PA have been found in several spore-forming Gram-positive bacteria, and share the ability to translocate toxic enzymes into the host cytosol.The PA monomer is organised mainly into antiparallel beta-sheets and has four domains: an N-terminal domain (domain 1) containing two calcium ions and the cleavage site for activating proteases; a heptamerisation domain (domain 2) containing a large flexible loop implicated in membrane insertion; a small domain of unknown function (domain 3); and a carboxy-terminal receptor-binding domain (domain 4) [PMID: 9039918].This entry represents domain 4 of PA, which has an immunoglobulin-like fold. Domain 4 plays a key role in cellular receptor recognition, as well as in pH-dependent pore formation[PMID: 19722284].