| Types | DnaRegion
|
| Roles | CDS
Coding
|
| Sequences | BBa_K1151001_sequence (Version 1)
|
Description
So called for emphasize its origins in Helicobacter pylori and its avidity for nickel. Consisting of 60 aminoacids, the protein is rich in histidine (28 residues, 46.7 %) and contains short repeating motifs, it exists as an equilibration of multimeric forms in solution, with 20-mers (approx. 136 kDa) being the predominant species. Hpn can bind tightly and reversibly up to five Ni2+ ions per each monomer of 7 kDa in a pH-dependent manner (pH 7.4 ). In H. pylori play an important role in storing nickel required to the survival of the bacterium.
Notes
The gene is designed on H.pylori genomic sequence and amplified by PCR
Source
synthesized by IDT (as gblock)
