| Types | DnaRegion
|
| Roles | Coding
CDS
|
| Sequences | BBa_K1154002_sequence (Version 1)
|
Description
The Saccharomyces cerevisiae HIS3 gene encodes imidazoleglycerol-phosphate dehydratase (IGPD), which catalyzes the interconversion of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate and 3-(imidazol-4-yl)-2-oxopropyl phosphate plus H2O. The dehydration reaction is a key step in the biosynthesis of histidine in many bacteria, fungi and plants. The gene is routinely used as a selectable marker in yeast histidine auxotrophs harboring a genomic his3 mutation (e.g., his3-delta1). Although, it also compliments Escherichia coli hisB mutations (e.g., ΔhisB720::kan).
Notes
na
Source
Coding sequence is from the HIS3/YOR202W locus on yeast chromosome XV from coordinates 721946 to 722608.
