BBa_K1230005

BBa_K1230005 Version 1

Component

Source: http://parts.igem.org/Part:BBa_K1230005

Generated By: https://synbiohub.org/public/igem/igem2sbol/1

Date created: 2013-09-11 11:00:00

Date modified: 2015-05-08 01:09:44

-- No description --

Details

• Types: DnaRegion
• Roles: CDS; Coding
• Sequences: BBa_K1230005_sequence (Version 1)

Description

GW-Q5 is a cationic alpha-helical peptide designed de novo using the natural peptide Magainin as a template, upon which variants that maintained major structural determinants like electric charge, hydrophobicity and angular momentum were designed. This peptide showed antimicrobial activity against Gram-positive and Gram-negative bacteria, and in particular it showed a Minimab Inhibitory Concentration 4 ??g/ml against Vibrio harveyi, 8 ??g/ml against V. parahemoliticu,s and 8??g/ml against Escherichia coli3.

Reference
H.-T. Chou et al. / International Journal of Antimicrobial Agents 32 (2008) 130???138

Notes

Chou et al. synthesized GW-Q5 by solid-phase peptide synthesis, and thus they provide an Aminoacid sequence but no DNA sequence. Therefore we had to design a DNA sequence that had the codons corresponding to the given Peptide.

Source

Designed de novo by Chou et al. (2008)

Other Properties

• igem#experience: None
• igem#sampleStatus: It's complicated
• igem#status: Planning
• synbiohub#ownedBy: user/james
• synbiohub#ownedBy: user/myers
• synbiohub#topLevel: BBa_K1230005/1

Member of these Collections

• iGEM Parts Registry