| Types | DnaRegion
|
| Roles | Coding
CDS
|
| Sequences | BBa_K128003_sequence (Version 1)
|
Description
This sequence codes for a short peptide, found to competitively inhibit binding of S.mutans to the tooth surface (CG et al.; Nature Biotechnol. 1999). S.mutans takes in sugars and secretes lactic acid, causing dental cavities, so introduction of this peptide into the mouth prevents cavities. This part uses the modified Silver BioBrick prefix and suffix to allow for protein construction.
Notes
We used the modified Silver BioBrick prefix and suffix to make the construction of funcitonal fusion peptides possible.
Source
This peptide is a 20 amino acid section of the native S.mutans surface protein that binds to the glycoproteins of the teeth. It is taken straight from the 1999 Nature paper by CG Kelly et al. which discovered the efficacy of this peptide in competitive inhibition of S.mutans.
