BBa_K1458002

BBa_K1458002 Version 1

Component

Source:
http://parts.igem.org/Part:BBa_K1458002
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Reut Sapir
Date created: 2014-10-04 11:00:00
Date modified: 2015-05-08 01:10:32

ucp1 (Uncoupling protein 1)



Types
DnaRegion

Roles
CDS

Coding

Sequences BBa_K1458002_sequence (Version 1)

Description

ucp1 is the gene encoding UCP1 protein.

it is a Transmembrane protein naturally present in mitochondrias of brown adipose tissue. the gene itself is not encoded though in the mitochondrial genome but in the nuclear DNA, after translation it is taged and sent to the mitochondria.
UCP1 increases the permeability of the inner mitochondrial membrane to protons, allowing them to move from the inner membrane space to the mitochondrial matrix, bypassing ATP synthase. This process weakens the coupling of the electron transport chain to the production of ATP. In an attempt to raise the pH gradient negatively affected by UCP1, a fast oxidation of substrates occurs while the synthesis rate of ATP stays low and oxidation energy is released as heat instead.

UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides.

Notes

None

Source

http://www.ncbi.nlm.nih.gov/gene/7350#genomic-regions-transcripts-products

igem#experience
None
 
igem#sampleStatus
Not in stock
igem#status
Unavailable
 
rdf-schema#seeAlso
P25874
 
synbiohub#ownedBy
user/james
 
synbiohub#ownedBy
user/myers
 
synbiohub#topLevel
BBa_K1458002/1