Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Pascal Sartor
Date created: 2014-10-05 11:00:00
Date modified: 2015-05-08 01:10:38
Ecotropic murine leukemia virus (MuLV) receptor / Cationic amino acid transporter 1 (CAT-1)
| Types | DnaRegion |
| Roles | CDS Coding |
| Sequences | BBa_K1470000_sequence (Version 1) |
Description
The cationic amino acid transporter 1 (CAT-1) is a part of the CAT family which is the main entry gate for amino acids such as histidine, arginine or ornithin in mammalian cells. They enable the influx of their substrate in a NaStructure and virus recognition
CAT-1 is a 66 kDa membrane protein. It's built up of 622 amino acids contains 14 transmembrane domains. There are two sites for N-glycosylation in the third loop. Also a comparison between CAT-1 sequences from different species shows that region doesn't include conserved amino acids.
The glycosyled position is very important for virus' entry. The murine leukeamia virus is only able to enter the cell, when it detects the SLC7A1's sugar-bound moieties. Otherwise MuLV doesn't infect cells.