| Types | DnaRegion
|
| Roles | CDS
Coding
|
| Sequences | BBa_K1742001_sequence (Version 1)
|
Description
Diarrheal diseases caused by Vibrio cholera and enterotoxigenic Escherichia coli (ETEC) are worldwide health problems that might be prevented with vaccines based on edible plants expressing the B subunit from either the cholera toxin (CTB) or the E. coli heat labile toxin (LTB). The E. coli heat-labile enterotoxin (LT) is the major ETEC pathogenic factor. LT subunit B (LTB) is of special interest because its immunogenicity, adjuvant activity and lack of toxicity make it a viable antigen to vaccinate against ETEC diarrhea.
Notes
The protein consists of the E. coli enterotoxin beta subunit. It is codon optimized for plants and contains a C-terminus 6X Hys tag in order to detected by anti-Hys antibodies.
Source
The LTB protein was designed based on a publication that showed that it can be expressed in Nicotiana Benthamiana plants.
