| Types | DnaRegion
|
| Roles | polypeptide_domain
Protein_Domain
|
| Sequences | BBa_K1781001_sequence (Version 1)
|
Description
HER2 is the Human Epidermal Growth Factor 2 transmembrane receptor protein. It is located on all cells and when overexpressed this oncogene is known to induce some types of cancer. In recent years, it has been used as a biomarker. In this project, protein-protein interactions were analyzed and HER2 was identified as a perfect control. Its cytoplasmic tyrosine kinase domain was known to bind to antibodies such as trastuzumab, but more recently the affibody ZHER2 was created to bind to the protein with a higher affinity. In this case, we only needed the cytoplasmic domain for our use in the analysis of the HER2-ZHER2 binding.
Notes
We only needed the cytoplasmic domain, so we had to remove the rest of the protein.
Source
The full HER2 (Human Epidermal Growth Factor 2) protein
