Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Yujia Liu
Date created: 2016-10-10 11:00:00
Date modified: 2016-10-13 09:32:59
anti-microRNA-34c
| Types | DnaRegion |
| Roles | RNA mature_transcript_region |
| Sequences | BBa_K1940000_sequence (Version 1) |
Description
Anti- microRNA-34c can be used as a miR-34c detector. MiR-34c is significantly upregulated in Alzheimer's disease (AD) patients. Several researches have suggested that strategies to manipulate miR-34c could open a suitable novel virus-free therapeutic avenue to treat cognitive diseases. In this part, we designed 4 series antisense strand of miR-34c which are linked by 4 linkers. Anti- microRNA-34c is sensitive to the expression levels of miR-34c. And combined with a reporter, we can diagnose AD accurately and rapidly.Notes
4 copies of anti-microRNA-34c can enhance the detection sensitivity.Source
Homo sapiens (human),Chromosome 11, NC_000011.10 (111513439..111513515)| Sequence Annotation | Location | Component / Role(s) |
| anti-microRNA-34c anti-microRNA-34c anti-microRNA-34c anti-microRNA-34c linker linker linker | 20,42 50,72 80,102 110,132 73,79 43,49 103,109 | sequence_feature feature/misc feature/misc sequence_feature sequence_feature feature/misc feature/misc sequence_feature feature/misc sequence_feature feature/misc sequence_feature sequence_feature feature/misc |