Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: David Sanderson
Date created: 2016-08-12 11:00:00
Date modified: 2016-10-21 02:46:43
HDLEA1
| Types | DnaRegion |
| Roles | Coding CDS |
| Sequences | BBa_K2128004_sequence (Version 1) |
Description
This part is a member is a class of intrinsically disordered proteins called the Late Embryonic Abundant (LEA) proteins that become ordered when desiccated, thereby stabilizing DNA and protein cell components. This tardigrade unique protein is found in the mitochondria of tardigrade cells. When cloned into humans, they confer protection against osmotic stress as shown in the paper "Novel Mitochondria-Targeted Heat-Soluble Proteins Identified in the Anhydrobiotic Tardigrade Improve Osmotic Tolerance of Human Cells" by Sae Tanaka et al. 2015 Feb 12.It was taken from the genome of Ramazzottius varieornatus and optimized by the IDT Codon Optimization Tool for E. Coli K12.
Notes
This part was optimized by the IDT Codon Optimization Tool for E. Coli K12.Source
Ramazzottius varieornatus| Sequence Annotation | Location | Component / Role(s) |
| HDLEA1_ORF | 1,272 | CDS feature/cds |