BBa_K364312

BBa_K364312 Version 1

Component

Source: http://parts.igem.org/Part:BBa_K364312

Generated By: https://synbiohub.org/public/igem/igem2sbol/1

Created by: Lior Malka

Date created: 2010-09-29 11:00:00

Date modified: 2015-05-08 01:12:14

Human VDR hinge region

Details

• Types: DnaRegion
• Roles: CDS; Coding
• Sequences: BBa_K364312_sequence (Version 1)

Description

the vitamin D receptor (VDR) and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific geneproducts. In humans, the vitamin D receptor is encoded by the VDR gene.
Hinge region: Thought to be a flexible domain that connects the DBD with the LBD. Influences intracellular trafficking and subcellular distribution.

Notes

The reconstruction of the DBD to the hinge region and LBD will be done with RFC 25.

Source

Human VDR (of the nuclear hormone receptor superfamily)

Other Properties

• igem#experience: None
• igem#sampleStatus: It's complicated
• igem#status: Planning
• synbiohub#ownedBy: user/james
• synbiohub#ownedBy: user/myers
• synbiohub#topLevel: BBa_K364312/1

Member of these Collections

• iGEM Parts Registry